It is well established that cells sense chemical signals from their local microenvironment and
transduce them to the nucleus to regulate gene expression programmes. Although a number …

Mechanotransduction is the ability of a cell to sense mechanical cues from its
microenvironment and convert them into biochemical signals to elicit adaptive transcriptional …

Tissue injury disrupts the mechanical homeostasis that underlies normal tissue architecture
and function. The failure to resolve injury and restore homeostasis gives rise to progressive …

In cardiovascular tissues, changes in the mechanical properties of the extracellular matrix
are associated with cellular de-differentiation and with subsequent functional declines …

The extracellular matrix (ECM) is a complex network of macromolecules surrounding cells
providing structural support and stability to tissues. The understanding of the ECM and the …

The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

Immune responses are governed by signals from the tissue microenvironment, and in
addition to biochemical signals, mechanical cues and forces arising from the tissue, its …

Mutations in the LaminA gene are a common cause of monogenic dilated cardiomyopathy.
Here we show that mice with a cardiomyocyte-specific Lmna deletion develop cardiac failure …

Cells in the body reside within the extracellular matrix (ECM), a three-dimensional
environment that not only provides structural support for the cells, but also influences cellular …

Inadequate pancreatic β cell function underlies type 1 and type 2 diabetes mellitus.
Strategies to expand functional cells have focused on discovering and controlling …