Perivascular adipose tissue regulates vascular function by targeting vascular smooth muscle cells

L Chang, MT Garcia-Barrio, YE Chen - … , thrombosis, and vascular …, 2020 - Am Heart Assoc
Adipose tissues are present at multiple locations in the body. Most blood vessels are
surrounded with adipose tissue which is referred to as perivascular adipose tissue (PVAT) …

Immunomodulation strategies for the successful regeneration of a tissue‐engineered vascular graft

F Zhang, MW King - Advanced Healthcare Materials, 2022 - Wiley Online Library
Cardiovascular disease leads to the highest morbidity worldwide. There is an urgent need to
solve the lack of a viable arterial graft for patients requiring coronary artery bypass surgery …

Endothelialization of arterial vascular grafts by circulating monocytes

RJ Smith Jr, B Nasiri, J Kann, D Yergeau… - Nature …, 2020 - nature.com
Recently our group demonstrated that acellular tissue engineered vessels (A-TEVs)
comprised of small intestinal submucosa (SIS) immobilized with heparin and vascular …

Tissue engineered vascular grafts transform into autologous neovessels capable of native function and growth

KM Blum, JC Zbinden, AB Ramachandra… - Communications …, 2022 - nature.com
Background Tissue-engineered vascular grafts (TEVGs) have the potential to advance the
surgical management of infants and children requiring congenital heart surgery by creating …

[HTML][HTML] Implantation of VEGF-functionalized cell-free vascular grafts: regenerative and immunological response

RJ Smith Jr, T Yi, B Nasiri, CK Breuer… - The FASEB …, 2019 - ncbi.nlm.nih.gov
Recently, our group demonstrated that immobilized VEGF can capture flowing endothelial
cells (ECs) from the blood in vitro and promote endothelialization and patency of acellular …

血小板衍生生长因子BB 促进SD 大鼠骨髓间充质干细胞的增殖

姜涛, 吴硕, 李志强, 寿玺, 马依热 - 中国组织工程研究, 2021 - cjter.com
血小板衍生生长因子BB 促进SD 大鼠骨髓间充质干细胞的增殖 Page 1 1976 |中国组织工程研究
|第25卷|第13期|2021年5月 血小板衍生生长因子BB 促进SD 大鼠骨髓间充质干细胞的增殖 姜涛 …

Sex and Tamoxifen confound murine experimental studies in cardiovascular tissue engineering

KM Blum, LC Roby, JC Zbinden, YC Chang… - Scientific Reports, 2021 - nature.com
Tissue engineered vascular grafts hold promise for the creation of functional blood vessels
from biodegradable scaffolds. Because the precise mechanisms regulating this process are …

Hemodynamics and Wall Mechanics of Vascular Graft Failure

JM Szafron, EE Heng, J Boyd… - … and Vascular Biology, 2024 - Am Heart Assoc
Blood vessels are subjected to complex biomechanical loads, primarily from pressure-driven
blood flow. Abnormal loading associated with vascular grafts, arising from altered …

Heparin affinity-based IL-4 delivery to modulate macrophage phenotype and endothelial cell activity in vitro

F Zhang, JM Gluck, AC Brown… - … Applied Materials & …, 2023 - ACS Publications
Macrophages play a pivotal role in wound healing and tissue regeneration, as they are
rapidly recruited to the site of injury or implanted foreign material. Depending on their …

Electrospun tissue-engineered arterial graft thickness affects long-term composition and mechanics

YL Wu, JM Szafron, KM Blum, JC Zbinden… - … Engineering Part A, 2021 - liebertpub.com
Wall stress is often lower in tissue-engineered constructs than in comparable native tissues
due to the use of stiff polymeric materials having thicker walls. In this work, we sought to …