Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …

Challenges in the Elimination of Pediatric HIV-1 Infection | New England Journal of Medicine
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Background It is unknown if extremely early initiation of antiretroviral therapy (ART) may lead
to long-term ART-free HIV remission or cure. As a result, we studied 2 individuals recruited …

To investigate the possibility that HIV-1 replication in lymph nodes sustains the reservoir
during antiretroviral therapy (ART), we looked for evidence of viral replication in 5 donors …

It is clear that early ART has a greater impact in limiting the HIV reservoirs than later
treatment. However, latently infected long-lived memory CD4+ T cells persist in most early …

Background. Third-and fourth-generation immunoassays (IAs) are widely used in the
diagnosis of human immunodeficiency virus (HIV) infection. Antiretroviral therapy (ART) …

Background. Combination antiretroviral therapy (cART) generally suppresses the replication
of the human immunodeficiency virus type 1 (HIV-1) but does not cure the infection, because …

The 2015 Paediatric E uropean Network for Treatment of AIDS (PENTA) guidelines provide
practical recommendations on the management of HIV‐1 infection in children in E urope and …

Background The latent viral reservoir is the major obstacle to achieving HIV remission and
necessitates life-long antiretroviral therapy (ART) for HIV-infected individuals. Studies in …

The developing immune system is adapted to the exposure to a plethora of pathogenic and
non-pathogenic antigens encountered in utero and after birth, requiring a fine balance …