Epigenetic aging in adult neurogenesis
Neural stem cells (NSCs) in the hippocampus generate new neurons throughout life, which
functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal …
functionally contribute to cognitive flexibility and mood regulation. Yet adult hippocampal …
The epigenetic role of vitamin C in neurodevelopment
SJ Coker, CC Smith-Díaz, RM Dyson… - International Journal of …, 2022 - mdpi.com
The maternal diet during pregnancy is a key determinant of offspring health. Early studies
have linked poor maternal nutrition during gestation with a propensity for the development of …
have linked poor maternal nutrition during gestation with a propensity for the development of …
Circular RNA CircMAP3K5 acts as a MicroRNA-22-3p sponge to promote resolution of intimal hyperplasia via TET2-mediated smooth muscle cell differentiation
Z Zeng, L Xia, S Fan, J Zheng, J Qin, X Fan, Y Liu… - Circulation, 2021 - Am Heart Assoc
Background: Aberrant expression of circular RNA contributes to human diseases. Circular
RNAs regulate gene expression by sequestering specific microRNAs. In this study, we …
RNAs regulate gene expression by sequestering specific microRNAs. In this study, we …
METTL3-mediated m6A modification is required for cerebellar development
CX Wang, GS Cui, X Liu, K Xu, M Wang, XX Zhang… - PLoS …, 2018 - journals.plos.org
N 6-methyladenosine (m6A) RNA methylation is the most abundant modification on mRNAs
and plays important roles in various biological processes. The formation of m6A is catalyzed …
and plays important roles in various biological processes. The formation of m6A is catalyzed …
m6A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2
J Chen, YC Zhang, C Huang, H Shen… - Genomics …, 2019 - academic.oup.com
Abstract N 6-methyladenosine (m 6 A), catalyzed by the methyltransferase complex
consisting of Mettl3 and Mettl14, is the most abundant RNA modification in mRNAs and …
consisting of Mettl3 and Mettl14, is the most abundant RNA modification in mRNAs and …
[PDF][PDF] Tet2 rescues age-related regenerative decline and enhances cognitive function in the adult mouse brain
Restoring adult stem cell function provides an exciting approach for rejuvenating the aging
brain. However, molecular mechanisms mediating neurogenic rejuvenation remain elusive …
brain. However, molecular mechanisms mediating neurogenic rejuvenation remain elusive …
Epigenomic analysis of Parkinson's disease neurons identifies Tet2 loss as neuroprotective
LL Marshall, BA Killinger, E Ensink, P Li, KX Li… - Nature …, 2020 - nature.com
Parkinson's disease (PD) pathogenesis may involve the epigenetic control of enhancers that
modify neuronal functions. Here, we comprehensively examine DNA methylation at …
modify neuronal functions. Here, we comprehensively examine DNA methylation at …
[PDF][PDF] Ogt controls neural stem/progenitor cell pool and adult neurogenesis through modulating Notch signaling
J Chen, X Dong, X Cheng, Q Zhu, J Zhang, Q Li… - Cell reports, 2021 - cell.com
Ogt catalyzed O-linked N-acetylglucosamine (O-GlcNAcylation, O-GlcNAc) plays an
important function in diverse biological processes and diseases. However, the roles of Ogt in …
important function in diverse biological processes and diseases. However, the roles of Ogt in …
TET2 chemically modifies tRNAs and regulates tRNA fragment levels
C He, J Bozler, KA Janssen, JE Wilusz… - Nature structural & …, 2021 - nature.com
The ten-eleven translocation 2 (TET2) protein, which oxidizes 5-methylcytosine in DNA, can
also bind RNA; however, the targets and function of TET2–RNA interactions in vivo are not …
also bind RNA; however, the targets and function of TET2–RNA interactions in vivo are not …
[PDF][PDF] Non-coding and loss-of-function coding variants in TET2 are associated with multiple neurodegenerative diseases
JN Cochran, EG Geier, LW Bonham… - The American Journal of …, 2020 - cell.com
We conducted genome sequencing to search for rare variation contributing to early-onset
Alzheimer's disease (EOAD) and frontotemporal dementia (FTD). Discovery analysis was …
Alzheimer's disease (EOAD) and frontotemporal dementia (FTD). Discovery analysis was …