Less than a decade ago, it was shown that bromodomains, acetyl lysine 'reader'modules
found in proteins with varied functions, were highly tractable small-molecule targets. This is …

With the bromodomain (BRD) inhibitor JQ1, a remarkable success story of BRD4 as a novel
drug target has been set off that yielded many anti‐cancer drugs that are now in clinical …

Photoinduced hydroarylation of alkenes is an appealing synthetic strategy for arene
functionalization. Herein, we demonstrated that aryl radicals generated from electron …

Objective We have recently shown that priming of synovial fibroblasts (SFs) drives arthritis
flares. Pathogenic priming of SFs is essentially mediated by epigenetic reprogramming …

CD8+ tissue-resident memory T (Trm) cells and tumor-infiltrating lymphocytes (TIL) regulate
tumor immunity and immune surveillance. Characterization of Trm cells and TILs could help …

The reading of acetylation marks on histones by bromodomain (BRD) proteins is a key event
in transcriptional activation. Small molecule inhibitors targeting bromodomain and extra …

Simple Summary BRPF1 (also named as BR140) was identified 28 years ago, and it was not
until the past 5 years that its mutations in humans caught increasing attention. Those …

Cancer cells display pervasive changes in DNA methylation, disrupted patterns of histone
posttranslational modification, chromatin composition or organization and regulatory …

The bromodomain and extra terminal (BET) family of bromodomain‐containing proteins
(BCPs) have been the subject of extensive research over the past decade, resulting in a …

Bromodomains regulate chromatin remodeling and gene transcription through recognition of
acetylated lysines on histones and other proteins. Bromodomain-containing protein TAF1, a …