Microfluidic organs-on-chips
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing
methods that contains continuously perfused chambers inhabited by living cells arranged to …
methods that contains continuously perfused chambers inhabited by living cells arranged to …
Microfluidic platforms for mechanobiology
Mechanotransduction has been a topic of considerable interest since early studies
demonstrated a link between mechanical force and biological response. Until recently …
demonstrated a link between mechanical force and biological response. Until recently …
A 3D human triculture system modeling neurodegeneration and neuroinflammation in Alzheimer's disease
Alzheimer's disease (AD) is characterized by beta-amyloid accumulation, phosphorylated
tau formation, hyperactivation of glial cells, and neuronal loss. The mechanisms of AD …
tau formation, hyperactivation of glial cells, and neuronal loss. The mechanisms of AD …
Co-culture of tumor spheroids and fibroblasts in a collagen matrix-incorporated microfluidic chip mimics reciprocal activation in solid tumor microenvironment
Multicellular 3D culture and interaction with stromal components are considered essential
elements in establishing a 'more clinically relevant'tumor model. Matrix-embedded 3D …
elements in establishing a 'more clinically relevant'tumor model. Matrix-embedded 3D …
In vitro microfluidic models for neurodegenerative disorders
Microfluidic devices enable novel means of emulating neurodegenerative disease
pathophysiology in vitro. These organ‐on‐a‐chip systems can potentially reduce animal …
pathophysiology in vitro. These organ‐on‐a‐chip systems can potentially reduce animal …
Polydopamine-assisted osteoinductive peptide immobilization of polymer scaffolds for enhanced bone regeneration by human adipose-derived stem cells
Immobilization of osteoinductive molecules, including growth factors or peptides, on polymer
scaffolds is critical for improving stem cell-mediated bone tissue engineering. Such …
scaffolds is critical for improving stem cell-mediated bone tissue engineering. Such …
Microfluidics for neuronal cell and circuit engineering
The widespread adoption of microfluidic devices among the neuroscience and neurobiology
communities has enabled addressing a broad range of questions at the molecular, cellular …
communities has enabled addressing a broad range of questions at the molecular, cellular …
Recent developments in microfluidics-based chemotaxis studies
Microfluidic devices can better control cellular microenvironments compared to conventional
cell migration assays. Over the past few years, microfluidics-based chemotaxis studies …
cell migration assays. Over the past few years, microfluidics-based chemotaxis studies …
Microfluidic systems for stem cell-based neural tissue engineering
Neural tissue engineering aims at developing novel approaches for the treatment of
diseases of the nervous system, by providing a permissive environment for the growth and …
diseases of the nervous system, by providing a permissive environment for the growth and …
Three-dimensional brain-like microenvironments facilitate the direct reprogramming of fibroblasts into therapeutic neurons
Biophysical cues can improve the direct reprogramming of fibroblasts into neurons that can
be used for therapeutic purposes. However, the effects of a three-dimensional (3D) …
be used for therapeutic purposes. However, the effects of a three-dimensional (3D) …