In clinical trials, biochemical markers provide useful information on the drug's mode of
action, therapeutic response and side effect monitoring and can act as surrogate endpoints …

Ageing is accompanied by an inexorable loss of muscle mass and functionality and
represents a major risk factor for numerous diseases such as cancer, diabetes and …

Physical inactivity (PI) is a major risk factor of chronic diseases. A major aspect of PI is loss
of muscle mass and strength. The latter phenomenon significantly impacts daily life and …

Muscle fiber denervation is a major contributor to the decline in physical function observed
with aging. Denervation can occur through breakdown of the neuromuscular junctions (NMJ) …

Background Ageing is accompanied by a progressive loss of skeletal muscle mass and
strength, potentially determining the insurgence of sarcopenia. Evidence suggests that …

Background Efforts to enhance diagnostic measures for sarcopenia have led to an
increased focus on the screening utility of blood‐based biomarkers. In this regard …

Background Sarcopenia, a loss of skeletal muscle mass or function, affects up to 50% of
patients with inflammatory bowel disease (IBD) and is associated with poor clinical …

It is mandatory to manage musculoskeletal disorders in the elderly to prevent their becoming
bed-ridden or requiring long-term care. However, the prevalence of musculoskeletal …

Introduction: The increasingly popular microbiopsy is an appealing alternative to the more
invasive Bergström biopsy given the challenges associated with harvesting skeletal muscle …

Background Although handgrip strength (HGS) asymmetry has clinical screening utility, its
relevance to sarcopenia is unknown. This study examined the relationship between HGS …