Since it has become clear that adhesion receptors are trafficked through the endosomal
pathway and that this can influence their function, much effort has been invested in obtaining …

In tumor therapy, nanodrug delivery systems have gained momentum in the last decade.
However, its efficacy remains insufficient for clinical applications. The physical properties of …

Inhibitors of αvβ3 and αvβ5 integrin have entered clinical trials as antiangiogenic agents for
cancer treatment but generally have been unsuccessful. Here we present in vivo evidence …

Functional interplay between tumour cells and their neoplastic extracellular matrix plays a
decisive role in malignant progression of carcinomas. Here we provide a comprehensive …

The blood–brain barrier (BBB) is a tightly regulated barrier in the central nervous system.
Though the BBB is thought to be intact during neurodegenerative diseases such as …

Integrins are a class of transmembrane receptors that are involved in a wide range of
biological functions. Dysregulation of integrins has been implicated in many pathological …

Transforming growth factor-β (TGF-β) is a prototypical tumour-suppressor cytokine with
cytostatic and pro-apoptotic effects on most target cells; however, mechanisms of its pro …

Vascularization of bone defects is considered a crucial component to the successful
regeneration of large bone defects. Although vascular endothelial growth factor (VEGF) has …

Glioblastoma multiforme (GBM) are highly invasive and angiogenic malignancies with a
median survival time from diagnosis of< 15 months. Previous work has revealed robust …

The vitronectin receptor integrin αvβ3 promotes angiogenesis by mediating migration and
proliferation of endothelial cells, but also drives fibrogenic activation of hepatic stellate cells …