Mechanisms of chromosome folding and nuclear organization: their interplay and open questions
Microscopy and genomic approaches provide detailed descriptions of the three-dimensional
folding of chromosomes and nuclear organization. The fundamental question is how activity …
folding of chromosomes and nuclear organization. The fundamental question is how activity …
A walk through the SMC cycle: From catching DNAs to shaping the genome
R Oldenkamp, BD Rowland - Molecular cell, 2022 - cell.com
SMC protein complexes are molecular machines that provide structure to chromosomes.
These complexes bridge DNA elements and by doing so build DNA loops in cis and hold …
These complexes bridge DNA elements and by doing so build DNA loops in cis and hold …
Cohesin mediates DNA loop extrusion by a “swing and clamp” mechanism
BW Bauer, IF Davidson, D Canena, G Wutz, W Tang… - Cell, 2021 - cell.com
Structural maintenance of chromosomes (SMC) complexes organize genome topology in all
kingdoms of life and have been proposed to perform this function by DNA loop extrusion …
kingdoms of life and have been proposed to perform this function by DNA loop extrusion …
Cryo-EM structure of the human cohesin-NIPBL-DNA complex
As a ring-shaped adenosine triphosphatase (ATPase) machine, cohesin organizes the
eukaryotic genome by extruding DNA loops and mediates sister chromatid cohesion by …
eukaryotic genome by extruding DNA loops and mediates sister chromatid cohesion by …
A hold-and-feed mechanism drives directional DNA loop extrusion by condensin
IA Shaltiel, S Datta, L Lecomte, M Hassler… - Science, 2022 - science.org
Structural maintenance of chromosomes (SMC) protein complexes structure genomes by
extruding DNA loops, but the molecular mechanism that underlies their activity has …
extruding DNA loops, but the molecular mechanism that underlies their activity has …
All eukaryotic SMC proteins induce a twist of− 0.6 at each DNA loop extrusion step
Eukaryotes carry three types of structural maintenance of chromosome (SMC) protein
complexes, condensin, cohesin, and SMC5/6, which are ATP-dependent motor proteins that …
complexes, condensin, cohesin, and SMC5/6, which are ATP-dependent motor proteins that …
Human condensin I and II drive extensive ATP-dependent compaction of nucleosome-bound DNA
Structural maintenance of chromosomes (SMC) complexes are essential for genome
organization from bacteria to humans, but their mechanisms of action remain poorly …
organization from bacteria to humans, but their mechanisms of action remain poorly …
Cryo-EM structures of holo condensin reveal a subunit flip-flop mechanism
BG Lee, F Merkel, M Allegretti, M Hassler… - Nature structural & …, 2020 - nature.com
Complexes containing a pair of structural maintenance of chromosomes (SMC) family
proteins are fundamental for the three-dimensional (3D) organization of genomes in all …
proteins are fundamental for the three-dimensional (3D) organization of genomes in all …
Cryo-EM structure of MukBEF reveals DNA loop entrapment at chromosomal unloading sites
The ring-like structural maintenance of chromosomes (SMC) complex MukBEF folds the
genome of Escherichia coli and related bacteria into large loops, presumably by active DNA …
genome of Escherichia coli and related bacteria into large loops, presumably by active DNA …
The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity
X Sun, L He, H Liu, RF Thorne, T Zeng, L Liu, B Zhang… - Cell Metabolism, 2023 - cell.com
In response to adverse environmental conditions, embryonic development may reversibly
cease, a process termed diapause. Recent reports connect this phenomenon with the non …
cease, a process termed diapause. Recent reports connect this phenomenon with the non …