Acyl-CoA: diacylglycerol acyltransferase (DGAT, EC 2.3. 1.20) catalyzes the last reaction in
the acyl-CoA-dependent biosynthesis of triacylglycerol (TAG). DGAT activity resides mainly …

Fatty acids are primary metabolites synthesized by complex, elegant, and essential
biosynthetic machinery. Fatty acid synthases resemble an iterative assembly line, with an …

Recent concerns over the sustainability of petrochemical-based processes for production of
desired chemicals have fueled research into alternative modes of production. Metabolic …

New synthetic biology capabilities hold the promise of dramatically improving our ability to
engineer biological systems. However, a fundamental hurdle in realizing this potential is our …

Kinetic models of metabolism at a genome scale that faithfully recapitulate the effect of
multiple genetic interventions would be transformative in our ability to reliably design novel …

Type III polyketide synthases (PKS IIIs) contribute to the synthesis of many economically
important natural products, most of which are currently produced by direct extraction from …

Acetyl-CoA is a key metabolite precursor for the biosynthesis of lipids, polyketides,
isoprenoids, amino acids, and numerous other bioproducts which are used in various …

Abstract l-threonine is an important amino acid that can be added in food, medicine, or feed.
Here, the influence of glyoxylate shunt on an l-threonine producing strain Escherichia coli …

Metabolic engineering is used to improve titers, yields and generation rates for biochemical
products in host microbes such as Escherichia coli. A wide range of biochemicals are …

Branched-chain fatty acids (BCFAs) are key precursors of branched-chain fuels, which have
cold-flow properties superior to straight chain fuels. BCFA production in Gram-negative …