[HTML][HTML] Approaches, progress, and challenges to hepatitis C vaccine development
Risk factors for hepatitis C virus (HCV) infection vary, and there were an estimated 1.75
million new cases worldwide in 2015. The World Health Organization aims for a 90 …
million new cases worldwide in 2015. The World Health Organization aims for a 90 …
[HTML][HTML] Factors which contribute to the immunogenicity of non-replicating adenoviral vectored vaccines
L Coughlan - Frontiers in immunology, 2020 - frontiersin.org
Adenoviral vectors are a safe and potently immunogenic vaccine delivery platform. Non-
replicating Ad vectors possess several attributes which make them attractive vaccines for …
replicating Ad vectors possess several attributes which make them attractive vaccines for …
Changes in the global burden of chronic liver diseases from 2012 to 2017: the growing impact of NAFLD
Conclusions Our findings indicate that LINC00665 is involved in the NF‐κB signaling
activation in HCC cells and that the inflammatory LINC00665/PKR/NF‐κB loop plays …
activation in HCC cells and that the inflammatory LINC00665/PKR/NF‐κB loop plays …
AZD1222/ChAdOx1 nCoV-19 vaccination induces a polyfunctional spike protein–specific TH1 response with a diverse TCR repertoire
PA Swanson, M Padilla, W Hoyland… - Science translational …, 2021 - science.org
AZD1222 (ChAdOx1 nCoV-19), a replication-deficient simian adenovirus–vectored vaccine,
has demonstrated safety, efficacy, and immunogenicity against coronavirus disease 2019 in …
has demonstrated safety, efficacy, and immunogenicity against coronavirus disease 2019 in …
[PDF][PDF] Global distribution and prevalence of hepatitis C virus genotypes
JP Messina, I Humphreys, A Flaxman, A Brown… - …, 2015 - Wiley Online Library
Hepatitis C virus (HCV) exhibits high genetic diversity, characterized by regional variations
in genotype prevalence. This poses a challenge to the improved development of vaccines …
in genotype prevalence. This poses a challenge to the improved development of vaccines …
Pembrolizumab plus GX-188E therapeutic DNA vaccine in patients with HPV-16-positive or HPV-18-positive advanced cervical cancer: interim results of a single-arm …
Background Survival outcomes for patients with recurrent or advanced cervical cancer are
poor. Pembrolizumab has been approved for the treatment of recurrent or metastatic cervical …
poor. Pembrolizumab has been approved for the treatment of recurrent or metastatic cervical …
Who funded the research behind the Oxford–AstraZeneca COVID-19 vaccine?
S Cross, Y Rho, H Reddy, T Pepperrell, F Rodgers… - BMJ global …, 2021 - gh.bmj.com
Objectives The Oxford–AstraZeneca COVID-19 vaccine (ChAdOx1 nCoV-19, Vaxzevira or
Covishield) builds on two decades of research and development (R&D) into chimpanzee …
Covishield) builds on two decades of research and development (R&D) into chimpanzee …
A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory
L Swadling, S Capone, RD Antrobus, A Brown… - Science translational …, 2014 - science.org
A protective vaccine against hepatitis C virus (HCV) remains an unmet clinical need. HCV
infects millions of people worldwide and is a leading cause of liver cirrhosis and …
infects millions of people worldwide and is a leading cause of liver cirrhosis and …
[PDF][PDF] Costimulatory and coinhibitory receptor pathways in infectious disease
J Attanasio, EJ Wherry - Immunity, 2016 - cell.com
Costimulatory and inhibitory receptors play a key role in regulating immune responses to
infections. Recent translation of knowledge about inhibitory receptors such as CTLA-4 and …
infections. Recent translation of knowledge about inhibitory receptors such as CTLA-4 and …
Chimpanzee adenovirus vaccine generates acute and durable protective immunity against ebolavirus challenge
DA Stanley, AN Honko, C Asiedu, JC Trefry… - Nature medicine, 2014 - nature.com
Ebolavirus disease causes high mortality, and the current outbreak has spread unabated
through West Africa. Human adenovirus type 5 vectors (rAd5) encoding ebolavirus …
through West Africa. Human adenovirus type 5 vectors (rAd5) encoding ebolavirus …