We have analyzed FDA-approved macrocyclic drugs, clinical candidates, and the recent
literature to understand how macrocycles are used in drug discovery. Current drugs are …

Natural products (NPs) are primarily recognized as privileged structures to interact with
protein drug targets. Their unique characteristics and structural diversity continue to marvel …

Naturally occurring peptides with high membrane permeability often have ester bonds on
their backbones. However, the impact of amide-to-ester substitutions on the membrane …

Cyclic peptides extend the druggable target space due to their size, flexibility, and hydrogen-
bonding capacity. However, these properties impact also their passive membrane …

Molecular chameleons possess a flexibility that allows them to dynamically shield or expose
polar functionalities in response to the properties of the environment. Although the concept …

Intracellular protein–protein interactions (PPIs) are challenging targets for traditional drug
modalities. Macrocyclic peptides (MPs) prove highly effective PPI inhibitors in vitro and can …

Biochar when applied into soil, together with soil clay minerals, may provide habitats for soil
microbes and shift soil microbial community structure. Although several mechanisms have …

Self-assembled short peptides have intrigued scientists due to the convenience of synthesis,
good biocompatibility, low toxicity, inherent biodegradability and fast response to change in …

Herein, we report a novel strategy for the modification of peptides based on the introduction
of highly reactive hypervalent iodine reagents—ethynylbenziodoxolones (EBXs)—onto …

Cyclic peptides have received increasing attention over the recent years as potential
therapeutics for “undruggable” targets. One major obstacle is, however, their often relatively …