Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention
Research conducted during the past 30 years has increased our understanding of the
mechanisms involved in colorectal cancer initiation and development. The findings have …
mechanisms involved in colorectal cancer initiation and development. The findings have …
Genetic instabilities in human cancers
C Lengauer, KW Kinzler, B Vogelstein - Nature, 1998 - nature.com
Whether and how human tumours are genetically unstable has been debated for decades.
There is now evidence that most cancers may indeed be genetically unstable, but that the …
There is now evidence that most cancers may indeed be genetically unstable, but that the …
Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2020 for the clinical practice of hereditary colorectal cancer
N Tomita, H Ishida, K Tanakaya, T Yamaguchi… - International Journal of …, 2021 - Springer
Hereditary colorectal cancer (HCRC) accounts for< 5% of all colorectal cancer cases. Some
of the unique characteristics commonly encountered in HCRC cases include early age of …
of the unique characteristics commonly encountered in HCRC cases include early age of …
Hereditary colorectal cancer
HT Lynch, A De la Chapelle - New England Journal of Medicine, 2003 - Mass Medical Soc
Colorectal cancers among patients with a familial risk of this disorder account for
approximately one of five cases of this disease. Many cases can be prevented by the …
approximately one of five cases of this disease. Many cases can be prevented by the …
Molecular pathology of Lynch syndrome
Lynch syndrome (LS) is characterised by predisposition to colorectal, endometrial, and other
cancers and is caused by inherited pathogenic variants affecting the DNA mismatch repair …
cancers and is caused by inherited pathogenic variants affecting the DNA mismatch repair …
Genomic and epigenetic instability in colorectal cancer pathogenesis
WM Grady, JM Carethers - Gastroenterology, 2008 - Elsevier
Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …
[HTML][HTML] Screening for the Lynch syndrome (hereditary nonpolyposis colorectal cancer)
H Hampel, WL Frankel, E Martin… - … England Journal of …, 2005 - Mass Medical Soc
Background Germ-line mutations in the mismatch-repair genes MLH1, MSH2, MSH6, and
PMS2 lead to the development of the Lynch syndrome (hereditary nonpolyposis colorectal …
PMS2 lead to the development of the Lynch syndrome (hereditary nonpolyposis colorectal …
Feasibility of screening for Lynch syndrome among patients with colorectal cancer
Purpose Identifying individuals with Lynch syndrome (LS) is highly beneficial. However, it is
unclear whether microsatellite instability (MSI) or immunohistochemistry (IHC) should be …
unclear whether microsatellite instability (MSI) or immunohistochemistry (IHC) should be …
The colorectal adenoma–carcinoma sequence
A Leslie, FA Carey, NR Pratt… - British Journal of …, 2002 - Wiley Online Library
Background: It is widely accepted that the adenoma–carcinoma sequence represents the
process by which most, if not all, colorectal cancers arise. The evidence supporting this …
process by which most, if not all, colorectal cancers arise. The evidence supporting this …
The molecular basis of Turcot's syndrome
SR Hamilton, B Liu, RE Parsons… - … England Journal of …, 1995 - Mass Medical Soc
Background Turcot's syndrome is characterized clinically by the concurrence of a primary
brain tumor and multiple colorectal adenomas. We attempted to define the syndrome at the …
brain tumor and multiple colorectal adenomas. We attempted to define the syndrome at the …