Research conducted during the past 30 years has increased our understanding of the
mechanisms involved in colorectal cancer initiation and development. The findings have …

Whether and how human tumours are genetically unstable has been debated for decades.
There is now evidence that most cancers may indeed be genetically unstable, but that the …

Hereditary colorectal cancer (HCRC) accounts for< 5% of all colorectal cancer cases. Some
of the unique characteristics commonly encountered in HCRC cases include early age of …

Colorectal cancers among patients with a familial risk of this disorder account for
approximately one of five cases of this disease. Many cases can be prevented by the …

Lynch syndrome (LS) is characterised by predisposition to colorectal, endometrial, and other
cancers and is caused by inherited pathogenic variants affecting the DNA mismatch repair …

Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …

Background Germ-line mutations in the mismatch-repair genes MLH1, MSH2, MSH6, and
PMS2 lead to the development of the Lynch syndrome (hereditary nonpolyposis colorectal …

Purpose Identifying individuals with Lynch syndrome (LS) is highly beneficial. However, it is
unclear whether microsatellite instability (MSI) or immunohistochemistry (IHC) should be …

Background: It is widely accepted that the adenoma–carcinoma sequence represents the
process by which most, if not all, colorectal cancers arise. The evidence supporting this …

Background Turcot's syndrome is characterized clinically by the concurrence of a primary
brain tumor and multiple colorectal adenomas. We attempted to define the syndrome at the …