Various environmental stressors, such as extreme temperatures (hot and cold), pathogens,
predators and insufficient food, can threaten life. Remarkable progress has recently been …

Body temperature regulation is a fundamental homeostatic function that is governed by the
central nervous system in homeothermic animals, including humans. The central …

Stress affects core body temperature (T c). Many kinds of stress induce transient,
monophasic hyperthermia, which diminishes gradually if the stressor is terminated. Stronger …

Endotoxic fever is regulated by endogenous factors that provide pro-and anti-pyretic signals
at different points along the febrigenic pathway, from the periphery to the brain. Current …

This short review focusses on the inflammatory reflex, which acts in negative feedback
manner to moderate the inflammatory consequences of systemic microbial challenge. The …

Psychological stress‐induced hyperthermia is a fundamental autonomic response in
mammals. However, the central circuitry underlying this stress response is poorly …

This review first considers how mammalian body temperature regulation evolved, and how
the brain's responses to thermoregulatory challenges are likely to be organised differently …

Hairless skin acts as a heat exchanger between body and environment, and thus greatly
contributes to body temperature regulation by changing blood flow to the skin (cutaneous) …

In this Paton Lecture I have tried to trace the key experiments that have developed ideas on
how the brain regulates the cardiovascular system. It is a personal view and inevitably …

A reduction of heat loss to the environment through increased cutaneous vasoconstrictor
(CVC) sympathetic outflow contributes to elevated body temperature during fever. We …