Preclinical models of human disease provide powerful tools for therapeutic discovery but
have limitations. This problem is especially apparent in the field of acute kidney injury (AKI) …

Under physiological states, the nervous system and the kidneys communicate with each
other to maintain normal body homeostasis. However, pathological states disrupt this …

Background Acute lung injury caused by renal ischemia–reperfusion is one of the leading
causes of acute kidney injury-related death. Dexmedetomidine, an α 2-adrenergic agonist …

The high mortality rates associated with acute kidney injury are mainly due to extra-renal
complications that occur following distant-organ involvement. Damage to these organs …

The homeostasis and health of an organism depend on the coordinated interaction of
specialized organs, which is regulated by interorgan communication networks of circulating …

New Findings What is central question of this study What are the differences between a
traditional renal pedicle‐clamping model of acute kidney injury and models with occluded …

Objective (s): Acute lung injury (ALI) is a common complication of distant organ dysfunction
induced by acute kidney injury (AKI). Toll-like receptors (TLRs) have a critical role in …

To diagnose renal function using a biochip capable of detecting SERS and to assess
Raman measurements taken from a bilateral renal ischemia model and the feasibility of …

Methods: Renal ischemia-reperfusion injury (I/R) was induced by bilateral occlusion of the
renal pedicles for 60 minutes, followed by 24 hours of reperfusion; sham-operated rats …

Homoeostasis and health of multicellular organisms with multiple organs depends on
interorgan communication. Tissue injury in one organ disturbs this homoeostasis and can …