Genetic correlates of phenotypic heterogeneity in autism
The substantial phenotypic heterogeneity in autism limits our understanding of its genetic
etiology. To address this gap, here we investigated genetic differences between autistic …
etiology. To address this gap, here we investigated genetic differences between autistic …
Functional neurogenomics in autism spectrum disorders: A decade of progress
LK Bicks, DH Geschwind - Current Opinion in Neurobiology, 2024 - Elsevier
Advances in autism spectrum disorder (ASD) genetics have identified many genetic causes,
reflecting remarkable progress while at the same time identifying challenges such as …
reflecting remarkable progress while at the same time identifying challenges such as …
Multiplexed functional genomic assays to decipher the noncoding genome
Linkage disequilibrium and the incomplete regulatory annotation of the noncoding genome
complicates the identification of functional noncoding genetic variants and their causal …
complicates the identification of functional noncoding genetic variants and their causal …
[HTML][HTML] Autistic spectrum disorder (ASD)–Gene, molecular and pathway signatures linking systemic inflammation, mitochondrial dysfunction, transsynaptic signalling …
Background Despite advances in autism spectrum disorder (ASD) research and the vast
genomic, transcriptomic, and proteomic data available, there are still controversies …
genomic, transcriptomic, and proteomic data available, there are still controversies …
Genetic relationships between attention-deficit/hyperactivity disorder, autism spectrum disorder, and intelligence
S Rao, A Baranova, Y Yao, J Wang, F Zhang - Neuropsychobiology, 2022 - karger.com
Introduction: Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder
(ASD) commonly co-occur; both traits exert an influence on intelligence scores. Genetic …
(ASD) commonly co-occur; both traits exert an influence on intelligence scores. Genetic …
Maternal and early-life exposure to antibiotics and the risk of autism and Attention-Deficit Hyperactivity Disorder in childhood: A Swedish population-based cohort …
LL Njotto, J Simin, R Fornes, I Odsbu, I Mussche… - Drug Safety, 2023 - Springer
Introduction Antibiotics represent the most common type of medication used during
pregnancy and infancy. Antibiotics have been proposed as a possible factor in changes in …
pregnancy and infancy. Antibiotics have been proposed as a possible factor in changes in …
Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure
V Hollestein, G Poelmans, NJ Forde… - Translational …, 2023 - nature.com
The excitatory/inhibitory (E/I) imbalance hypothesis posits that imbalance between excitatory
(glutamatergic) and inhibitory (GABAergic) mechanisms underlies the behavioral …
(glutamatergic) and inhibitory (GABAergic) mechanisms underlies the behavioral …
Shared genetics between autism spectrum disorder and attention-deficit/hyperactivity disorder and their association with extraversion
Background Deciphering the genetic relationships between autism spectrum disorder (ASD)
and attention-deficit/hyperactivity disorder (ADHD) may uncover underlining shared …
and attention-deficit/hyperactivity disorder (ADHD) may uncover underlining shared …
Epigenetic changes in sperm are associated with paternal and child quantitative autistic traits in an autism-enriched cohort
JI Feinberg, R Schrott, C Ladd-Acosta… - Molecular …, 2024 - nature.com
There is a need to consider paternal contributions to autism spectrum disorder (ASD) more
strongly. Autism etiology is complex, and heritability is not explained by genetics alone …
strongly. Autism etiology is complex, and heritability is not explained by genetics alone …
A human leukocyte antigen imputation study uncovers possible genetic interplay between gut inflammatory processes and autism spectrum disorders
L Lombardi, S Le Clerc, CL Wu, J Bouassida… - Translational …, 2023 - nature.com
Autism spectrum disorders (ASD) are neurodevelopmental conditions that are for subsets of
individuals, underpinned by dysregulated immune processes, including inflammation …
individuals, underpinned by dysregulated immune processes, including inflammation …