Genetic correlates of phenotypic heterogeneity in autism

V Warrier, X Zhang, P Reed, A Havdahl, TM Moore… - Nature Genetics, 2022 - nature.com
The substantial phenotypic heterogeneity in autism limits our understanding of its genetic
etiology. To address this gap, here we investigated genetic differences between autistic …

Functional neurogenomics in autism spectrum disorders: A decade of progress

LK Bicks, DH Geschwind - Current Opinion in Neurobiology, 2024 - Elsevier
Advances in autism spectrum disorder (ASD) genetics have identified many genetic causes,
reflecting remarkable progress while at the same time identifying challenges such as …

Multiplexed functional genomic assays to decipher the noncoding genome

YA Cooper, Q Guo, DH Geschwind - Human Molecular Genetics, 2022 - academic.oup.com
Linkage disequilibrium and the incomplete regulatory annotation of the noncoding genome
complicates the identification of functional noncoding genetic variants and their causal …

[HTML][HTML] Autistic spectrum disorder (ASD)–Gene, molecular and pathway signatures linking systemic inflammation, mitochondrial dysfunction, transsynaptic signalling …

M Gevezova, Y Sbirkov, V Sarafian, K Plaimas… - Brain, behavior, & …, 2023 - Elsevier
Background Despite advances in autism spectrum disorder (ASD) research and the vast
genomic, transcriptomic, and proteomic data available, there are still controversies …

Genetic relationships between attention-deficit/hyperactivity disorder, autism spectrum disorder, and intelligence

S Rao, A Baranova, Y Yao, J Wang, F Zhang - Neuropsychobiology, 2022 - karger.com
Introduction: Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder
(ASD) commonly co-occur; both traits exert an influence on intelligence scores. Genetic …

Maternal and early-life exposure to antibiotics and the risk of autism and Attention-Deficit Hyperactivity Disorder in childhood: A Swedish population-based cohort …

LL Njotto, J Simin, R Fornes, I Odsbu, I Mussche… - Drug Safety, 2023 - Springer
Introduction Antibiotics represent the most common type of medication used during
pregnancy and infancy. Antibiotics have been proposed as a possible factor in changes in …

Excitatory/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure

V Hollestein, G Poelmans, NJ Forde… - Translational …, 2023 - nature.com
The excitatory/inhibitory (E/I) imbalance hypothesis posits that imbalance between excitatory
(glutamatergic) and inhibitory (GABAergic) mechanisms underlies the behavioral …

Shared genetics between autism spectrum disorder and attention-deficit/hyperactivity disorder and their association with extraversion

A Baranova, J Wang, H Cao, JH Chen, J Chen… - Psychiatry …, 2022 - Elsevier
Background Deciphering the genetic relationships between autism spectrum disorder (ASD)
and attention-deficit/hyperactivity disorder (ADHD) may uncover underlining shared …

Epigenetic changes in sperm are associated with paternal and child quantitative autistic traits in an autism-enriched cohort

JI Feinberg, R Schrott, C Ladd-Acosta… - Molecular …, 2024 - nature.com
There is a need to consider paternal contributions to autism spectrum disorder (ASD) more
strongly. Autism etiology is complex, and heritability is not explained by genetics alone …

A human leukocyte antigen imputation study uncovers possible genetic interplay between gut inflammatory processes and autism spectrum disorders

L Lombardi, S Le Clerc, CL Wu, J Bouassida… - Translational …, 2023 - nature.com
Autism spectrum disorders (ASD) are neurodevelopmental conditions that are for subsets of
individuals, underpinned by dysregulated immune processes, including inflammation …