Background and purpose: Stroke is a leading cause of death and acquired disability in
adults today. Inflammation plays an important role in the pathophysiology of stroke. The …

Systemic inflammation, neurovascular dysfunction, and coagulopathy often occur
concurrently in neuropathologies. Neutrophils and platelets have crucial synergistic roles in …

Background The role of neutrophil extracellular traps (NETs) in procoagulant activity (PCA)
in stroke patients caused by thromboembolic occlusion of the internal carotid artery (ICA) …

Acute ischemic stroke remains the primary cause of disability worldwide. For patients with
large vessel occlusions, intravenous thrombolysis followed by mechanical thrombectomy …

Reperfusion therapies are the mainstay of acute ischemic stroke (AIS) treatments and
overall improve functional outcome. Among the established complications of intravenous …

Dysregulated platelet functions contribute to the development and progression of ischemic
stroke. Utilizing mice with a platelet-specific deletion of cyclophilin D (CypD), a mediator of …

Objective Symptomatic intracerebral hemorrhage (sICH) is a common complication of acute
ischemic stroke (AIS) associated with limited treatments and poor outcomes. We aimed to …

The composition of ischemic stroke thrombi has gained an increasing amount of interest in
recent years. The implementation of endovascular procedures in standard stroke care has …

Background: Futile recanalization (FR) continues to raise concern despite the success of
endovascular thrombectomy (EVT) in acute ischemic stroke (AIS). Understanding the …

Objective To assess whether interleukin-6 (IL-6) level is a marker of futile reperfusion in
patients with acute ischemic stroke (AIS) with large vessel occlusion treated with mechanical …