PI3K/Akt/mTOR pathway and its role in cancer therapeutics: are we making headway?

Y Peng, Y Wang, C Zhou, W Mei, C Zeng - Frontiers in oncology, 2022 - frontiersin.org
Cancer is a severe public health issue that is a leading cause of mortality globally. It is also
an impediment to improving life expectancy worldwide. Furthermore, the global burden of …

Food anthocyanins: Malvidin and its glycosides as promising antioxidant and anti-inflammatory agents with potential health benefits

A Merecz-Sadowska, P Sitarek, T Kowalczyk, K Zajdel… - Nutrients, 2023 - mdpi.com
Anthocyanins are flavonoid compounds that are abundantly present in fruits and vegetables.
These compounds contribute to the color of these foods and offer various health benefits to …

Ultrasound-Chargeable Persistent Luminescence Nanoparticles to Generate Self-Propelled Motion and Photothermal/NO Therapy for Synergistic Tumor Treatment

Z Zhang, H Yan, W Cao, S Xie, P Ran, K Wei, X Li - ACS nano, 2023 - ACS Publications
Cancer phototherapy indicates advantages in ease of manipulation, negligible drug
resistance, and spatiotemporal control but is confronted with challenges in tumor cell …

Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy

Q Li, Z Li, T Luo, H Shi - Molecular biomedicine, 2022 - Springer
Abstract The PI3K/AKT/mTOR and RAF/MEK/ERK pathways are commonly activated by
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …

PRMT5 activates AKT via methylation to promote tumor metastasis

L Huang, XO Zhang, EJ Rozen, X Sun, B Sallis… - Nature …, 2022 - nature.com
Abstract Protein arginine methyltransferase 5 (PRMT5) is the primary methyltransferase
generating symmetric-dimethyl-arginine marks on histone and non-histone proteins. PRMT5 …

Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

MR Chaudhary, S Chaudhary, Y Sharma, TA Singh… - Biogerontology, 2023 - Springer
Aging accompanied by several age-related complications, is a multifaceted inevitable
biological progression involving various genetic, environmental, and lifestyle factors. The …

Targeting PI3K/Akt/mTOR pathway by different flavonoids: a cancer chemopreventive approach

TA Zughaibi, M Suhail, M Tarique, S Tabrez - International Journal of …, 2021 - mdpi.com
Cancer is, globally, one of the main causes of death. Even though various therapies are
available, they are still painful because of their adverse side effects. Available treatments …

Cancer chemoresistance and its mechanisms: Associated molecular factors and its regulatory role

S Kannampuzha, AV Gopalakrishnan - Medical Oncology, 2023 - Springer
Cancer therapy has advanced from tradition chemotherapy methods to targeted therapy,
novel drug delivery mechanisms, combination therapies etc. Although several novel …

Advancement in precision diagnosis and therapeutic for triple-negative breast cancer: Harnessing diagnostic potential of CRISPR-cas & engineered CAR T-cells …

V Nayak, S Patra, KRB Singh, B Ganguly… - Environmental …, 2023 - Elsevier
Cancer is characterized by uncontrolled cell growth, disrupted regulatory pathways, and the
accumulation of genetic mutations. These mutations across different types of cancer lead to …

Deciphering the signaling mechanisms of osteosarcoma tumorigenesis

BK Nirala, T Yamamichi, JT Yustein - International Journal of Molecular …, 2023 - mdpi.com
Osteosarcoma (OS) is the predominant primary bone tumor in the pediatric and adolescent
populations. It has high metastatic potential, with the lungs being the most common site of …