PI3K/Akt/mTOR pathway and its role in cancer therapeutics: are we making headway?
Y Peng, Y Wang, C Zhou, W Mei, C Zeng - Frontiers in oncology, 2022 - frontiersin.org
Cancer is a severe public health issue that is a leading cause of mortality globally. It is also
an impediment to improving life expectancy worldwide. Furthermore, the global burden of …
an impediment to improving life expectancy worldwide. Furthermore, the global burden of …
Food anthocyanins: Malvidin and its glycosides as promising antioxidant and anti-inflammatory agents with potential health benefits
A Merecz-Sadowska, P Sitarek, T Kowalczyk, K Zajdel… - Nutrients, 2023 - mdpi.com
Anthocyanins are flavonoid compounds that are abundantly present in fruits and vegetables.
These compounds contribute to the color of these foods and offer various health benefits to …
These compounds contribute to the color of these foods and offer various health benefits to …
Ultrasound-Chargeable Persistent Luminescence Nanoparticles to Generate Self-Propelled Motion and Photothermal/NO Therapy for Synergistic Tumor Treatment
Z Zhang, H Yan, W Cao, S Xie, P Ran, K Wei, X Li - ACS nano, 2023 - ACS Publications
Cancer phototherapy indicates advantages in ease of manipulation, negligible drug
resistance, and spatiotemporal control but is confronted with challenges in tumor cell …
resistance, and spatiotemporal control but is confronted with challenges in tumor cell …
Targeting the PI3K/AKT/mTOR and RAF/MEK/ERK pathways for cancer therapy
Q Li, Z Li, T Luo, H Shi - Molecular biomedicine, 2022 - Springer
Abstract The PI3K/AKT/mTOR and RAF/MEK/ERK pathways are commonly activated by
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …
mutations and chromosomal translocation in vital targets. The PI3K/AKT/mTOR signaling …
PRMT5 activates AKT via methylation to promote tumor metastasis
Abstract Protein arginine methyltransferase 5 (PRMT5) is the primary methyltransferase
generating symmetric-dimethyl-arginine marks on histone and non-histone proteins. PRMT5 …
generating symmetric-dimethyl-arginine marks on histone and non-histone proteins. PRMT5 …
Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies
MR Chaudhary, S Chaudhary, Y Sharma, TA Singh… - Biogerontology, 2023 - Springer
Aging accompanied by several age-related complications, is a multifaceted inevitable
biological progression involving various genetic, environmental, and lifestyle factors. The …
biological progression involving various genetic, environmental, and lifestyle factors. The …
Targeting PI3K/Akt/mTOR pathway by different flavonoids: a cancer chemopreventive approach
Cancer is, globally, one of the main causes of death. Even though various therapies are
available, they are still painful because of their adverse side effects. Available treatments …
available, they are still painful because of their adverse side effects. Available treatments …
Cancer chemoresistance and its mechanisms: Associated molecular factors and its regulatory role
S Kannampuzha, AV Gopalakrishnan - Medical Oncology, 2023 - Springer
Cancer therapy has advanced from tradition chemotherapy methods to targeted therapy,
novel drug delivery mechanisms, combination therapies etc. Although several novel …
novel drug delivery mechanisms, combination therapies etc. Although several novel …
Advancement in precision diagnosis and therapeutic for triple-negative breast cancer: Harnessing diagnostic potential of CRISPR-cas & engineered CAR T-cells …
Cancer is characterized by uncontrolled cell growth, disrupted regulatory pathways, and the
accumulation of genetic mutations. These mutations across different types of cancer lead to …
accumulation of genetic mutations. These mutations across different types of cancer lead to …
Deciphering the signaling mechanisms of osteosarcoma tumorigenesis
Osteosarcoma (OS) is the predominant primary bone tumor in the pediatric and adolescent
populations. It has high metastatic potential, with the lungs being the most common site of …
populations. It has high metastatic potential, with the lungs being the most common site of …