Parvalbumin is a calcium-binding protein present in inhibitory interneurons that play an
essential role in regulating many physiological processes, such as intracellular signaling …

Cortical GABAergic interneurons are critical components of neural networks. They provide
local and long-range inhibition and help coordinate network activities involved in various …

CACNA1A deletions cause epilepsy, ataxia, and a range of neurocognitive deficits,
including inattention, impulsivity, intellectual deficiency and autism. To investigate the …

Autism spectrum disorder (ASD) is a series of highly inherited neurodevelopmental
disorders. Loss-of-function (LOF) mutations in the CACNA2D3 gene are associated with …

Recessive and de novo mutations in the TRIO gene are associated with intellectual
deficiency (ID), autism spectrum disorder (ASD) and developmental epileptic …

Plasticity of principal cells and inhibitory interneurons underlies hippocampal memory.
Bidirectional modulation of somatostatin cell mTORC1 activity, a crucial translational control …

The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) integrates multiple
signals to regulate critical cellular processes such as mRNA translation, lipid biogenesis …

Epilepsy frequently leads to cognitive dysfunction and approaches to treatment remain
limited. Although regular exercise effectively improves learning and memory functions …

Hippocampal somatostatin (SOM) cells are dendrite-projecting inhibitory interneurons. CA1
SOM cells receive major excitatory inputs from pyramidal cells (PC-SOM synapses) which …

The way in which aberrant neural circuits contribute to epilepsy remains unclear. To
elucidate this question, we dissected the circuit mechanisms underlying epileptogenesis …