Using negative controls to adjust for unmeasured confounding bias in time series studies

JK Hu, EJ Tchetgen Tchetgen, F Dominici - Nature Reviews Methods …, 2023 - nature.com
Unmeasured confounding threatens the validity of observational studies. Negative control
variables (NCs) are variables that either do not cause the outcome of interest or are not …

Measuring frailty in Medicare data: development and validation of a claims-based frailty index

DH Kim, S Schneeweiss, RJ Glynn… - The Journals of …, 2018 - academic.oup.com
Background Frailty is a key determinant of health status and outcomes of health care
interventions in older adults that is not readily measured in Medicare data. This study aimed …

Deprescribing research in nursing home residents using routinely collected healthcare data: a conceptual framework

C Thorpe, J Niznik, A Li - BMC geriatrics, 2023 - Springer
Background Efforts are needed to strengthen evidence and guidance for appropriate
deprescribing for older nursing home (NH) residents, who are disproportionately affected by …

Identifying the population with serious illness: the “denominator” challenge

AS Kelley, E Bollens-Lund - Journal of palliative medicine, 2018 - liebertpub.com
Background: To ensure seriously ill people and their families receive high-quality primary
and specialty palliative care services, rigorous methods are needed to prospectively identify …

Association of inappropriate outpatient pediatric antibiotic prescriptions with adverse drug events and health care expenditures

AM Butler, DS Brown, MJ Durkin… - JAMA network …, 2022 - jamanetwork.com
Importance Nonguideline antibiotic prescribing for the treatment of pediatric infections is
common, but the consequences of inappropriate antibiotics are not well described. Objective …

Validation of a claims-based frailty index against physical performance and adverse health outcomes in the health and retirement study

DH Kim, RJ Glynn, J Avorn, LA Lipsitz… - The Journals of …, 2019 - academic.oup.com
Background A claims-based frailty index (CFI) was developed based on a deficit-
accumulation approach using self-reported health information. This study aimed to …

Development of a claims-based frailty indicator anchored to a well-established frailty phenotype

JB Segal, HY Chang, Y Du, JD Walston… - Medical care, 2017 - journals.lww.com
Background: Fried and colleagues described a frailty phenotype measured in the
Cardiovascular Health Study (CHS). This phenotype is manifest when≥ 3 of the following …

Association of frailty with 30-day outcomes for acute myocardial infarction, heart failure, and pneumonia among elderly adults

H Kundi, RK Wadhera, JB Strom, LR Valsdottir… - JAMA …, 2019 - jamanetwork.com
Importance The addition of a claims-based frailty metric to traditional comorbidity-based risk-
adjustment models for acute myocardial infarction (AMI), heart failure (HF), and pneumonia …

Measuring frailty in administrative claims data: comparative performance of four claims-based frailty measures in the US Medicare data

DH Kim, E Patorno, A Pawar, H Lee… - The Journals of …, 2020 - academic.oup.com
Background There has been increasing effort to measure frailty in the US Medicare data.
The performance of claims-based frailty measures has not been compared. Methods This …

Updating and validating the US veterans affairs frailty index: transitioning from ICD-9 to ICD-10

D Cheng, C DuMontier, C Yildirim… - The Journals of …, 2021 - academic.oup.com
Abstract Background The Veterans Affairs Frailty Index (VA-FI) is an electronic frailty index
developed to measure frailty using administrative claims and electronic health records data …