Understanding relationships between heart failure and arrhythmias, important causes of
suffering and sudden death, remains an unmet goal for biomedical researchers and …

L-type Ca2+ channels are mediators of Ca2+ influx and the regulatory events accompanying
it and are pivotal in the function and dysfunction of ventricular cardiac myocytes. L-type …

It is well established that the auxiliary Cavβ subunit regulates calcium channel density in the
plasma membrane, but the cellular mechanism by which this occurs has remained unclear …

There are several definitions of biomarkers. A biomarker is a characteristic that can be
objectively measured and evaluated as an indicator of a physiological as well as a …

Rationale: Disruption in subcellular targeting of Ca2+ signaling complexes secondary to
changes in cardiac myocyte structure may contribute to the pathophysiology of a variety of …

Background Anthracycline therapy is limited by cardiotoxicity. Currently no diagnostic
parameter is available allowing ubiquitous and reliable detection of preclinical anthracycline …

Excessive activation of calmodulin kinase II (CaMKII) causes arrhythmias and heart failure,
but the cellular mechanisms for CaMKII-targeted proteins causing disordered cell membrane …

Pathological cardiac hypertrophy (PCH) is associated with the development of arrhythmia
and congestive heart failure. While calcium (Ca2+) is implicated in hypertrophic signaling …

Background—Tropomyosin (TM), an essential actin-binding protein, is central to the control
of calcium-regulated striated muscle contraction. Although TPM1α (also called α-TM) is the …

The pancreatic islets of Langerhans secrete several hormones critical for glucose
homeostasis. The β-cells, the major cellular component of the pancreatic islets, secrete …