▪ Abstract The ability of pathogens to obtain iron from transferrins, ferritin, hemoglobin, and
other iron-containing proteins of their host is central to whether they live or die. To combat …

Biochemical, serological and microbiological methods have been used to dissect pathogens
and identify the components useful for vaccine development. Although successful in many …

The human-and animal-adapted lineages of the Mycobacterium tuberculosis complex
(MTBC) are thought to have expanded from a common progenitor in Africa. However, the …

The distribution of 20 variable regions resulting from insertion-deletion events in the
genomes of the tubercle bacilli has been evaluated in a total of 100 strains of …

The genus Mycobacterium contains several slow-growing human pathogens, including
Mycobacterium tuberculosis, Mycobacterium leprae, and Mycobacterium avium …

Prevalent since pre-history, human tuberculosis—caused by the pathogen Mycobacterium
tuberculosis—remains a major source of death worldwide. Moreover, increasing drug …

Unlike many pathogens that are overtly toxic to their hosts, the primary virulence determinant
of Mycobacterium tuberculosis appears to be its ability to persist for years or decades within …

Abstract Background The genome of Mycobacterium tuberculosis H37Rv has five copies of
a cluster of genes known as the ESAT-6 loci. These clusters contain members of the CFP-10 …

Although the virulences and host ranges differ among members of the Mycobacterium
tuberculosis complex (TBC; M. tuberculosis, M. africanum, M. canettii, M. microti, M. bovis …

Analysis of mycobacterial strains that have lost their ability to cause disease is a powerful
approach to identify yet unknown virulence determinants and pathways involved in …