Adverse reactions to snake antivenom, and their prevention and treatment

HA de Silva, NM Ryan… - British journal of clinical …, 2016 - Wiley Online Library
Antivenom is the mainstay of treatment of snakebite envenoming. However, adverse
reactions to snake antivenom that is available are common in many parts of the world where …

Snakebite envenoming from a global perspective: Towards an integrated approach

JM Gutiérrez, D Williams, HW Fan, DA Warrell - Toxicon, 2010 - Elsevier
Snakebite envenoming is a neglected public health challenge of compelling importance in
many regions of the world, particularly sub-Saharan Africa, Asia, Latin America and Papua …

Current treatment for venom-induced consumption coagulopathy resulting from snakebite

K Maduwage, GK Isbister - PLoS neglected tropical diseases, 2014 - journals.plos.org
Venomous snakebite is considered the single most important cause of human injury from
venomous animals worldwide. Coagulopathy is one of the commonest important systemic …

Complications of Bothrops, Porthidium, and Bothriechis snakebites in Colombia. A clinical and epidemiological study of 39 cases attended in a university hospital

R Otero, J Gutiérrez, MB Mesa, E Duque, O Rodrı́guez… - Toxicon, 2002 - Elsevier
The clinical and epidemiological features, as well as complications presented by 39 patients
with Bothrops, Porthidium and Bothriechis snakebites, are described. Patients were admitted …

Snakebites and ethnobotany in the northwest region of Colombia: Part III: Neutralization of the haemorrhagic effect of Bothrops atrox venom

R Otero, V Núñez, J Barona, R Fonnegra… - Journal of …, 2000 - Elsevier
Thirty-one of 75 extracts of plants used by traditional healers for snakebites, had moderate
or high neutralizing ability against the haemorrhagic effect of Bothrops atrox venom from …

Efficacy, safety, and use of snake antivenoms in the United States

RC Dart, J McNally - Annals of emergency medicine, 2001 - Elsevier
The mainstay of hospital treatment for venomous snakebite is antivenom. There is currently
only one antivenom available in the United States for the treatment of pit viper …

Pharmacokinetic-pharmacodynamic relationships of immunoglobulin therapy for envenomation

JM Gutiérrez, G León, B Lomonte - Clinical pharmacokinetics, 2003 - Springer
Parenteral administration of horse-and sheep-derived antivenoms constitutes the
cornerstone in the therapy of envenomations induced by animal bites and stings. Depending …

Epidemiological, clinical and therapeutic aspects of Bothrops asper bites

R Otero-Patino - Toxicon, 2009 - Elsevier
Bothrops asper inflicts the majority of snakebites in Central America and in the northern
regions of South America, mostly affecting young agricultural workers in rural settings. This …

Hematologic effects and complications of snake envenoming

I Berling, GK Isbister - Transfusion medicine reviews, 2015 - Elsevier
Hematologic abnormalities are the most common effects of snake envenoming globally.
Venom-induced consumption coagulopathy (VICC) is the commonest and most important …

Pathogenic mechanisms underlying adverse reactions induced by intravenous administration of snake antivenoms

G León, M Herrera, Á Segura, M Villalta, M Vargas… - Toxicon, 2013 - Elsevier
Snake antivenoms are formulations of immunoglobulins, or immunoglobulin fragments,
purified from the plasma of animals immunized with snake venoms. Their therapeutic …