Obstructive sleep apnoea heterogeneity and cardiovascular disease

S Redline, A Azarbarzin, Y Peker - Nature Reviews Cardiology, 2023 - nature.com
Obstructive sleep apnoea (OSA), characterized by recurrent periods of upper airway
obstruction and intermittent hypoxaemia, is prevalent in patients with cardiovascular disease …

Sleep apnea: types, mechanisms, and clinical cardiovascular consequences

S Javaheri, F Barbe, F Campos-Rodriguez… - Journal of the American …, 2017 - jacc.org
Sleep apnea is highly prevalent in patients with cardiovascular disease. These disordered
breathing events are associated with a profile of perturbations that include intermittent …

Sleep Disordered Breathing and Cardiovascular Disease: JACC State-of-the-Art Review

MR Cowie, D Linz, S Redline, VK Somers… - Journal of the American …, 2021 - jacc.org
Sleep disordered breathing causes repetitive episodes of nocturnal hypoxemia, sympathetic
nervous activation, and cortical arousal, often associated with excessive daytime sleepiness …

Sleep apnea and cardiovascular disease: lessons from recent trials and need for team science

LF Drager, RD McEvoy, F Barbe, G Lorenzi-Filho… - Circulation, 2017 - Am Heart Assoc
Emerging research highlights the complex interrelationships between sleep-disordered
breathing and cardiovascular disease, presenting clinical and research opportunities as well …

[HTML][HTML] Association of obstructive sleep apnea with hypertension: a systematic review and meta-analysis

H Hou, Y Zhao, W Yu, H Dong, X Xue, J Ding… - Journal of global …, 2018 - ncbi.nlm.nih.gov
Background Obstructive sleep apnea (OSA) is a sleep disorder characterized as complete or
partial upper airflow cessation during sleep. Although it has been widely accepted that OSA …

Phenotypes in obstructive sleep apnea: a definition, examples and evolution of approaches

AV Zinchuk, MJ Gentry, J Concato, HK Yaggi - Sleep medicine reviews, 2017 - Elsevier
Obstructive sleep apnea (OSA) is a complex and heterogeneous disorder and the apnea
hypopnea index alone can not capture the diverse spectrum of the condition. Enhanced …

Phenotypic subtypes of OSA: a challenge and opportunity for precision medicine

A Zinchuk, HK Yaggi - Chest, 2020 - Elsevier
Current strategies for the management of OSA reflect a one-size-fits-all approach. Diagnosis
and severity of OSA are based on the apnea-hypopnea index and treatment initiated with …

Polysomnographic phenotypes and their cardiovascular implications in obstructive sleep apnoea

AV Zinchuk, S Jeon, BB Koo, X Yan, DM Bravata, L Qin… - Thorax, 2018 - thorax.bmj.com
Background Obstructive sleep apnoea (OSA) is a heterogeneous disorder, and improved
understanding of physiologic phenotypes and their clinical implications is needed. We …

Sleep apnoea and the brain: a complex relationship

I Rosenzweig, M Glasser, D Polsek… - The Lancet …, 2015 - thelancet.com
Intermittent hypoxia, reoxygenation, and hypercapnia or hypocapnia occur in both adults
and children during untreated apnoea and hypopnoea, along with changes in cerebral …

Association of obstructive sleep apnoea with cardiovascular events in women and men with acute coronary syndrome

X Wang, J Fan, R Guo, W Hao, W Gong… - European …, 2023 - Eur Respiratory Soc
Background The impact of sex on the association of obstructive sleep apnoea (OSA) with
recurrent cardiovascular events following acute coronary syndrome (ACS) remains …