Chromosomes in all domains of life are well-defined structural entities with complex
hierarchical organization. The regulation of this hierarchical organization and its functional …

In their natural habitats, organisms encounter numerous external stimuli and must be able to
sense and adapt to those stimuli to survive. Unlike mutations, epigenetic changes do not …

The histone-like nucleoid structuring (H-NS) protein is a DNA binding factor, found in
gammaproteobacteria, with functional equivalents in diverse microbes. Universally, such …

Nucleoid-associated proteins (NAPs) play a central role in chromosome organization and
environment-responsive transcription regulation. The Bacillus subtilis-encoded NAP Rok …

Sporulating bacteria can retreat into long-lasting dormant spores that preserve the capacity
to germinate when propitious. However, how the revival transcriptional program is …

Background Bacteria and their viruses, bacteriophages, are the most abundant entities of
the gut microbiota, a complex community of microorganisms associated with human health …

Genomic mutations allow bacteria to adapt rapidly to adverse stress environments. The
three-dimensional conformation of the genome may also play an important role in …

Bacterial chromosomes are large molecules that need to be highly compacted to fit inside
the cells. Chromosome compaction must facilitate and maintain key biological processes …

The three‐dimensional architecture of the bacterial chromosome is intertwined with genome
processes such as transcription and replication. Conspicuously so, that the structure of the …

The spatial organization of eukaryotic genomes is linked to their biological functions,
although it is not clear how this impacts the overall evolution of a genome. Here, we uncover …