Formation of chromatin subcompartments by phase separation
Chromatin is partitioned on multiple length scales into subcompartments that differ from
each other with respect to their molecular composition and biological function. It is a key …
each other with respect to their molecular composition and biological function. It is a key …
Redox signaling by reactive electrophiles and oxidants
The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …
Mouse heterochromatin adopts digital compaction states without showing hallmarks of HP1-driven liquid-liquid phase separation
The formation of silenced and condensed heterochromatin foci involves enrichment of
heterochromatin protein 1 (HP1). HP1 can bridge chromatin segments and form liquid …
heterochromatin protein 1 (HP1). HP1 can bridge chromatin segments and form liquid …
A protein-tagging system for signal amplification in gene expression and fluorescence imaging
Signals in many biological processes can be amplified by recruiting multiple copies of
regulatory proteins to a site of action. Harnessing this principle, we have developed a …
regulatory proteins to a site of action. Harnessing this principle, we have developed a …
Liquid–liquid phase separation in chromatin
K Rippe - Cold Spring Harbor perspectives in biology, 2022 - cshperspectives.cshlp.org
In eukaryotic cells, protein and RNA factors involved in genome activities like transcription,
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …
RNA processing, DNA replication, and repair accumulate in self-organizing membraneless …
A comprehensive review of fluorescence correlation spectroscopy
Fluorescence correlation spectroscopy (FCS) is a powerful technique for quantification of
molecular dynamics, and it has been widely applied in diverse fields, eg, biomedicine …
molecular dynamics, and it has been widely applied in diverse fields, eg, biomedicine …
Evolutionary pathways and trajectories in antibiotic resistance
Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …
provided a wealth of information, but knowledge regarding “what happened” has precluded …
Open sesame: how transition fibers and the transition zone control ciliary composition
FR Garcia-Gonzalo, JF Reiter - Cold Spring Harbor …, 2017 - cshperspectives.cshlp.org
Cilia are plasma membrane protrusions that act as cellular propellers or antennae. To
perform these functions, cilia must maintain a composition distinct from those of the …
perform these functions, cilia must maintain a composition distinct from those of the …
Bio‐Coreactant‐Enhanced Electrochemiluminescence Microscopy of Intracellular Structure and Transport
C Ma, S Wu, Y Zhou, HF Wei, J Zhang… - Angewandte …, 2021 - Wiley Online Library
A bio‐coreactant‐enhanced electrochemiluminescence (ECL) microscopy realizes the ECL
imaging of intracellular structure and dynamic transport. This microscopy uses Ru (bpy) 32+ …
imaging of intracellular structure and dynamic transport. This microscopy uses Ru (bpy) 32+ …
Polymer physics indicates chromatin folding variability across single-cells results from state degeneracy in phase separation
The spatial organization of chromosomes has key functional roles, yet how chromosomes
fold remains poorly understood at the single-molecule level. Here, we employ models of …
fold remains poorly understood at the single-molecule level. Here, we employ models of …