Investigations in the last 10 years have revealed a new category of neurological diseases
mediated by antibodies against cell surface and synaptic proteins. There are currently 16 …

The rapid expansion in the number of encephalitis disorders associated with autoantibodies
against neuronal proteins has led to an incremental increase in use of the term “autoimmune …

Objective: This nationwide study gives a detailed description of the clinical features and long-
term outcome of anti–leucine-rich glioma-inactivated 1 (LGI1) encephalitis. Methods: We …

Antibodies that immunoprecipitate 125I-α-dendrotoxin-labelled voltage-gated potassium
channels extracted from mammalian brain tissue have been identified in patients with …

Objective: To describe a distinctive seizure semiology that closely associates with voltage‐
gated potassium channel (VGKC)‐complex/Lgi1 antibodies and commonly precedes the …

Background Voltage-gated potassium channels are thought to be the target of antibodies
associated with limbic encephalitis. However, antibody testing using cells expressing …

The discovery of disorders that are associated with antibodies to neuronal cell-surface
proteins has led to a paradigm shift in our understanding of CNS autoimmunity. These …

Abstract Leucine-rich glioma-inactivated 1 (LGI1) is a secreted neuronal protein that forms a
trans-synaptic complex that includes the presynaptic disintegrin and metalloproteinase …

Voltage-gated potassium channel complex antibodies, particularly those directed against
leucine-rich glioma inactivated 1, are associated with a common form of limbic encephalitis …

The discovery, in 2010, of autoantibodies against the extracellular proteins LGI1 and Caspr2
facilitated a change of view regarding the clinical importance of voltage-gated potassium …