Inhibitory activities of indolizine derivatives: a patent review

KM Dawood, AA Abbas - Expert Opinion on Therapeutic Patents, 2020 - Taylor & Francis
Introduction Indolizines are structural isomers with indoles. Although several indole-based
commercial drugs are available in the market, none of the indolizine-based drugs are …

Multicomponent synthesis of chromophores–The one-pot approach to functional π-systems

L Brandner, TJJ Müller - Frontiers in Chemistry, 2023 - frontiersin.org
Multicomponent reactions, conducted in a domino, sequential or consecutive fashion, have
not only considerably enhanced synthetic efficiency as one-pot methodology, but they have …

Design, synthesis, characterization, and anti-tubercular activity of novel ethyl-3-benzoyl-6, 8-difluoroindolizine-1-carboxylate analogues: Molecular target identification …

P Mundhe, S Kidwai, SM Saini, HR Singh… - Journal of Molecular …, 2023 - Elsevier
A series of novel Ethyl-3-benzoyl-6, 8-difluoroindolizine-1-carboxylate analogues (4a-r)
were synthesized by reacting 3, 5-difluoropyridine, with phenacyl bromide to get quaternary …

Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme

KN Venugopala, S Chandrashekharappa… - Journal of Enzyme …, 2021 - Taylor & Francis
Abstract A series of 1, 2, 3-trisubstituted indolizines (2a–2f, 3a–3d, and 4a–4c) were
screened for in vitro whole-cell anti-tubercular activity against the susceptible H37Rv and …

Chiral Phosphoric Acid-Catalyzed Asymmetric Friedel–Crafts Addition of Indolizine to Cyclic N-Sulfonyl Imine

P Subba, MM Sadhu, VK Singh - The Journal of Organic …, 2023 - ACS Publications
A highly efficient chiral phosphoric acid-catalyzed enantioselective Friedel–Crafts addition of
indolizine to cyclic N-sulfonyl imine has been established. The newly developed protocol …

Investigation of antifungal properties of synthetic dimethyl-4-bromo-1-(substituted benzoyl) pyrrolo [1, 2-a] quinoline-2, 3-dicarboxylates analogues: Molecular docking …

V Uppar, S Chandrashekharappa, C Shivamallu, SP… - Molecules, 2021 - mdpi.com
Candida albicans, an opportunistic fungal pathogen, frequently colonizes immune-
compromised patients and causes mild to severe systemic reactions. Only few antifungal …

Photocatalytic C–H Disulfuration for the Preparation of Indolizine-3-disulfides

S Wu, D Hu, X Wan, J Zhao, Q He, Z Su… - The Journal of Organic …, 2022 - ACS Publications
A photocatalytic C–H disulfuration of indolizines was developed, giving an approach to a
wide variety of indolizine-3-disulfides with good yields. Trisulfide dioxides were explored as …

Cytotoxicity and Antimycobacterial Properties of Pyrrolo[1,2-a]quinoline Derivatives: Molecular Target Identification and Molecular Docking Studies

KN Venugopala, V Uppar, S Chandrashekharappa… - Antibiotics, 2020 - mdpi.com
A series of ethyl 1-(substituted benzoyl)-5-methylpyrrolo [1, 2-a] quinoline-3-carboxylates 4a–
f and dimethyl 1-(substituted benzoyl)-5-methylpyrrolo [1, 2-a] quinoline-2, 3-dicarboxylates …

Tandem-Michael-cyclization cascade to make pyridines: Use of electron-deficient acetylenes for the synthesis of indolizines in aqueous media

K Lakshmikanth, SM Saini, ST Dorai… - Tetrahedron, 2023 - Elsevier
A mild, greener approach via tandem-Michael-cyclization cascade reaction towards the
construction of a group of di-and tri-differently substituted indolizine with a broad scope of …

One-pot organocatalyzed synthesis of tricyclic indolizines

LA Zeoly, LV Acconcia, MT Rodrigues… - Organic & …, 2023 - pubs.rsc.org
Indolizines and their saturated derivatives are important structural motifs present in several
biologically active compounds of both natural and synthetic origin. We describe herein a one …