Biocatalysis making waves in organic chemistry

U Hanefeld, F Hollmann, CE Paul - Chemical Society Reviews, 2022 - pubs.rsc.org
Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

Enzymes for pharmaceutical and therapeutic applications

GK Meghwanshi, N Kaur, S Verma… - Biotechnology and …, 2020 - Wiley Online Library
Enzymes are highly efficient and selective biocatalysts, present in the living beings. They
exist in enormous varieties in terms of the types of reactions catalyzed by them for instance …

Transaminases for industrial biocatalysis: novel enzyme discovery

SA Kelly, S Mix, TS Moody, BF Gilmore - Applied microbiology and …, 2020 - Springer
Transaminases (TAms) are important enzymes for the production of chiral amines for the
pharmaceutical and fine chemical industries. Novel TAms for use in these industries have …

A plurizyme with transaminase and hydrolase activity catalyzes cascade reactions

S Roda, L Fernandez‐Lopez, M Benedens… - Angewandte …, 2022 - Wiley Online Library
Engineering dual‐function single polypeptide catalysts with two abiotic or biotic catalytic
entities (or combinations of both) supporting cascade reactions is becoming an important …

Creation of a (R)-β-Transaminase by Directed Evolution of d-Amino Acid Aminotransferase

H Jeon, AD Pagar, H Kang, P Giri, SP Nadarajan… - ACS …, 2022 - ACS Publications
β-Transaminases (β-TAs) have shown considerable potential as biocatalysts for the
synthesis of chiral β-and γ-amino acid. Herein, a (R)-β-TA was successfully created by the …

One-pot biocatalytic synthesis of nylon monomers from cyclohexanol using Escherichia coli-based concurrent cascade consortia

S Sarak, TP Khobragade, H Jeon, AD Pagar, P Giri… - Green …, 2021 - pubs.rsc.org
We developed a multienzyme biocatalytic cascade with high atom efficiency and a self-
sufficient redox network for the synthesis of nylon monomers without adding auxiliary …

Deracemization of Racemic Amines to Enantiopure (R)‐ and (S)‐amines by Biocatalytic Cascade Employing ω‐Transaminase and Amine Dehydrogenase

S Yoon, MD Patil, S Sarak, H Jeon, GH Kim… - …, 2019 - Wiley Online Library
A one‐pot deracemization strategy for α‐chiral amines is reported involving an
enantioselective deamination to the corresponding ketone followed by a stereoselective …

An integrated cofactor/co‐product recycling cascade for the biosynthesis of nylon monomers from cycloalkylamines

S Sarak, S Sung, H Jeon, MD Patil… - Angewandte Chemie …, 2021 - Wiley Online Library
We report a highly atom‐efficient integrated cofactor/co‐product recycling cascade
employing cycloalkylamines as multifaceted starting materials for the synthesis of nylon …

[HTML][HTML] Metabolic engineering of Pseudomonas putida KT2440 for medium-chain-length fatty alcohol and ester production from fatty acids

C Lu, EO Akwafo, RH Wijffels, VAPM Dos Santos… - Metabolic …, 2023 - Elsevier
Medium-chain-length fatty alcohols have broad applications in the surfactant, lubricant, and
cosmetic industries. Their acetate esters are widely used as flavoring and fragrance …

Enabling biocatalysis in high‐concentration organic cosolvent by enzyme gate engineering

F Cheng, MY Li, DJ Wei, XJ Zhang… - Biotechnology and …, 2022 - Wiley Online Library
Biocatalysis in high‐concentration organic solvents (OSs) offers many advantages, but
realizing this process remains a huge challenge. An R‐selective ω‐amine transaminase …