Life of RISC: Formation, action, and degradation of RNA-induced silencing complex

H Iwakawa, Y Tomari - Molecular cell, 2022 - cell.com
Small RNAs regulate a wide variety of biological processes by repressing the expression of
target genes at the transcriptional and post-transcriptional levels. To achieve these …

MicroRNAs: from mechanism to organism

PJ Dexheimer, L Cochella - Frontiers in cell and developmental …, 2020 - frontiersin.org
MicroRNAs (miRNAs) are short, regulatory RNAs that act as post-transcriptional repressors
of gene expression in diverse biological contexts. The emergence of small RNA-mediated …

Towards a molecular understanding of microRNA-mediated gene silencing

S Jonas, E Izaurralde - Nature reviews genetics, 2015 - nature.com
MicroRNAs (miRNAs) are a conserved class of small non-coding RNAs that assemble with
Argonaute proteins into miRNA-induced silencing complexes (miRISCs) to direct post …

The functions of microRNAs: mRNA decay and translational repression

H Iwakawa, Y Tomari - Trends in cell biology, 2015 - cell.com
MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs, which regulate
complementary mRNAs by inducing translational repression and mRNA decay. Although …

RNA-mediated epigenetic regulation of gene expression

D Holoch, D Moazed - Nature Reviews Genetics, 2015 - nature.com
Diverse classes of RNA, ranging from small to long non-coding RNAs, have emerged as key
regulators of gene expression, genome stability and defence against foreign genetic …

Long noncoding RNAs in plants

AT Wierzbicki, T Blevins… - Annual Review of Plant …, 2021 - annualreviews.org
Plants have an extraordinary diversity of transcription machineries, including five nuclear
DNA-dependent RNA polymerases. Four of these enzymes are dedicated to the production …

Biogenesis, turnover, and mode of action of plant microRNAs

K Rogers, X Chen - The Plant Cell, 2013 - academic.oup.com
MicroRNAs (miRNAs) are small RNAs that control gene expression through silencing of
target mRNAs. Mature miRNAs are processed from primary miRNA transcripts by the …

RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond

SE Castel, RA Martienssen - Nature Reviews Genetics, 2013 - nature.com
A growing number of functions are emerging for RNA interference (RNAi) in the nucleus, in
addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm …

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC

MR Fabian, N Sonenberg - Nature structural & molecular biology, 2012 - nature.com
Since their discovery almost two decades ago, microRNAs (miRNAs) have been shown to
function by post-transcriptionally regulating protein accumulation. Understanding how …

Small RNAs: big impact on plant development

M D'Ario, S Griffiths-Jones, M Kim - Trends in plant science, 2017 - cell.com
While the role of proteins in determining cell identity has been extensively studied, the
contribution of small noncoding RNA molecules such as miRNAs and siRNAs has been also …