Life of RISC: Formation, action, and degradation of RNA-induced silencing complex
Small RNAs regulate a wide variety of biological processes by repressing the expression of
target genes at the transcriptional and post-transcriptional levels. To achieve these …
target genes at the transcriptional and post-transcriptional levels. To achieve these …
MicroRNAs: from mechanism to organism
PJ Dexheimer, L Cochella - Frontiers in cell and developmental …, 2020 - frontiersin.org
MicroRNAs (miRNAs) are short, regulatory RNAs that act as post-transcriptional repressors
of gene expression in diverse biological contexts. The emergence of small RNA-mediated …
of gene expression in diverse biological contexts. The emergence of small RNA-mediated …
Towards a molecular understanding of microRNA-mediated gene silencing
S Jonas, E Izaurralde - Nature reviews genetics, 2015 - nature.com
MicroRNAs (miRNAs) are a conserved class of small non-coding RNAs that assemble with
Argonaute proteins into miRNA-induced silencing complexes (miRISCs) to direct post …
Argonaute proteins into miRNA-induced silencing complexes (miRISCs) to direct post …
The functions of microRNAs: mRNA decay and translational repression
MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs, which regulate
complementary mRNAs by inducing translational repression and mRNA decay. Although …
complementary mRNAs by inducing translational repression and mRNA decay. Although …
RNA-mediated epigenetic regulation of gene expression
D Holoch, D Moazed - Nature Reviews Genetics, 2015 - nature.com
Diverse classes of RNA, ranging from small to long non-coding RNAs, have emerged as key
regulators of gene expression, genome stability and defence against foreign genetic …
regulators of gene expression, genome stability and defence against foreign genetic …
Long noncoding RNAs in plants
AT Wierzbicki, T Blevins… - Annual Review of Plant …, 2021 - annualreviews.org
Plants have an extraordinary diversity of transcription machineries, including five nuclear
DNA-dependent RNA polymerases. Four of these enzymes are dedicated to the production …
DNA-dependent RNA polymerases. Four of these enzymes are dedicated to the production …
Biogenesis, turnover, and mode of action of plant microRNAs
K Rogers, X Chen - The Plant Cell, 2013 - academic.oup.com
MicroRNAs (miRNAs) are small RNAs that control gene expression through silencing of
target mRNAs. Mature miRNAs are processed from primary miRNA transcripts by the …
target mRNAs. Mature miRNAs are processed from primary miRNA transcripts by the …
RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond
SE Castel, RA Martienssen - Nature Reviews Genetics, 2013 - nature.com
A growing number of functions are emerging for RNA interference (RNAi) in the nucleus, in
addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm …
addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm …
The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC
MR Fabian, N Sonenberg - Nature structural & molecular biology, 2012 - nature.com
Since their discovery almost two decades ago, microRNAs (miRNAs) have been shown to
function by post-transcriptionally regulating protein accumulation. Understanding how …
function by post-transcriptionally regulating protein accumulation. Understanding how …
Small RNAs: big impact on plant development
While the role of proteins in determining cell identity has been extensively studied, the
contribution of small noncoding RNA molecules such as miRNAs and siRNAs has been also …
contribution of small noncoding RNA molecules such as miRNAs and siRNAs has been also …