Lipids represent the most abundant molecular type in the brain, with a fat content of∼ 60%
of the dry brain weight in humans. Despite this fact, little attention has been paid to …

Axon loss contributes to many common neurodegenerative disorders. In healthy axons, the
axon survival factor NMNAT2 inhibits SARM1, the central executioner of programmed axon …

Based on the bidirectional interactions between neurology and cancer science, the
burgeoning field “cancer neuroscience” has been proposed. An important node in the …

Axon degeneration contributes to the disruption of neuronal circuit function in diseased and
injured nervous systems. Severed axons degenerate following the activation of an …

Sterile alpha and toll/interleukin receptor motif-containing 1 (SARM1) is a critical regulator of
axon degeneration that acts through hydrolysis of NAD+ following injury. Recent work has …

Neuronal cell death and subsequent brain dysfunction are hallmarks of aging and
neurodegeneration, but how the nearby healthy neurons (bystanders) respond to the death …

Phagocytic clearance of degenerating neurons is triggered by “eat-me” signals exposed on
the neuronal surface. The conserved neuronal eat-me signal phosphatidylserine (PS) and …

The clinical management of segmental nerve deficits faces significant challenges,
particularly in achieving substantial neural structural reconstruction and functional recovery …

Background Bioenergetic maladaptations and axonopathy are often found in the early
stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential …

The degeneration of axons and their terminals occurs following traumatic, toxic, or
genetically-induced insults. Common molecular mechanisms unite these disparate triggers …