Toxoplasma gondii is a parasite that infects a wide range of animals and causes zoonotic
infections in humans. Although it normally only results in mild illness in healthy individuals …

The intracellular parasite Toxoplasma gondii has long provided a tractable experimental
system to investigate how the immune system deals with intracellular infections. This review …

Toxoplasma gondii is an incredibly successful parasite owing in part to its ability to persist
within cells for the life of the host. Remarkably, at least 350 host species of T. gondii have …

Toxoplasma gondii is an exceptionally successful parasite that infects a very broad host
range, including humans, across the globe. The outcome of infection differs remarkably …

Macrophages play an essential role in the early immune response against Toxoplasma and
are the cell type preferentially infected by the parasite in vivo. Interferon gamma (IFNγ) elicits …

Toxoplasma gondii secretes protein effectors to subvert the human immune system
sufficiently to establish a chronic infection. Relative to murine infections, little is known about …

Toxoplasma virulence depends on its ability to evade or survive the toxoplasmacidal
mechanisms induced by interferon gamma (IFNγ). While many Toxoplasma genes involved …

The blood–brain barrier (BBB) efficiently protects the central nervous system (CNS) from
infectious insults. Yet, the apicomplexan parasite Toxoplasma gondii has a remarkable …

Abstract Proteins of the Wiskott-Aldrich syndrome protein (WASP) family play a central role
in regulating actin cytoskeletal dynamics in a wide range of cellular processes. Genetic …

Upon pathogen detection, macrophages normally stay sessile in tissues while dendritic cells
(DCs) migrate to secondary lymphoid tissues. The obligate intracellular protozoan …