Amyloids are a broad class of proteins and peptides that can misfold and assemble into long
unbranched fibrils with a cross-β conformation. These misfolding and aggregation events …

Turmeric (Curcuma longa), a rhizomatous herbaceous perennial plant of the ginger family,
has been used for the treatment of diabetes in Ayurvedic and traditional Chinese medicine …

In this article, we first designed and synthesized curcumin-based near-infrared (NIR)
fluorescence imaging probes for detecting both soluble and insoluble amyloid beta (Aβ) …

Near-infrared fluorescence (NIRF) molecular imaging has been widely applied to monitoring
therapy of cancer and other diseases in preclinical studies; however, this technology has not …

Alzheimer's disease (AD) is a high mortality and high disability rates neurodegenerative
disease characterized by irreversible progression and poses a significant social and …

Turn-on fluorescence imaging is routinely studied; however, turn-on chemiluminescence
has been rarely explored for in vivo imaging. Herein, we report the design and validation of …

One of the early pathological hallmarks of Alzheimer׳ s disease (AD) is the deposition of
amyloid-β (Aβ) plaques in the brain. There has been a tremendous interest in the …

We designed and synthesized a BODIPY-based probe (BAP-1) for the imaging of β-amyloid
plaques in the brain. In binding experiments in vitro, BAP-1 showed excellent affinity for …

Alzheimer's disease (AD) is an irreversible neurodegenerative disorder that has a
progression that is closely associated with oxidative stress. It has long been speculated that …

It has been hypothesized that misfolding and misassembly of proteins into various
aggregation states contribute to several neurodegenerative diseases. For instance, amyloid …