m6A modification: recent advances, anticancer targeted drug discovery and beyond

LJ Deng, WQ Deng, SR Fan, MF Chen, M Qi, WY Lyu… - Molecular cancer, 2022 - Springer
Abstract Abnormal N6-methyladenosine (m6A) modification is closely associated with the
occurrence, development, progression and prognosis of cancer, and aberrant m6A …

The roles and implications of RNA m6A modification in cancer

X Deng, Y Qing, D Horne, H Huang… - Nature Reviews Clinical …, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …

[HTML][HTML] Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

J Xiong, J He, J Zhu, J Pan, W Liao, H Ye, H Wang… - Molecular cell, 2022 - cell.com
Tumor-infiltrating myeloid cells (TIMs) are crucial cell populations involved in tumor immune
escape, and their functions are regulated by multiple epigenetic mechanisms. The precise …

[HTML][HTML] METTL3 inhibits antitumor immunity by targeting m6A-BHLHE41-CXCL1/CXCR2 axis to promote colorectal cancer

H Chen, Y Pan, Q Zhou, C Liang, CC Wong, Y Zhou… - Gastroenterology, 2022 - Elsevier
Background & Aims N 6-Methyladenosine (m 6 A) is the most prevalent RNA modification
and recognized as an important epitranscriptomic mechanism in colorectal cancer (CRC) …

Fusobacterium nucleatum reduces METTL3-mediated m6A modification and contributes to colorectal cancer metastasis

S Chen, L Zhang, M Li, Y Zhang, M Sun, L Wang… - Nature …, 2022 - nature.com
Microbiota-host interactions play critical roles in colorectal cancer (CRC) progression,
however, the underlying mechanisms remain elusive. Here, we uncover that Fusobacterium …

[HTML][HTML] Excess body weight: Novel insights into its roles in obesity comorbidities

X Zhang, S Ha, HCH Lau, J Yu - Seminars in cancer biology, 2023 - Elsevier
Excess body weight is a global health problem due to sedentary lifestyle and unhealthy diet,
affecting 2 billion population worldwide. Obesity is a major risk factor for metabolic diseases …

Insights into N6-methyladenosine and programmed cell death in cancer

L Liu, H Li, D Hu, Y Wang, W Shao, J Zhong, S Yang… - Molecular cancer, 2022 - Springer
Abstract N6-methyladenosine (m6A) methylation, the most common form of internal RNA
modification in eukaryotes, has gained increasing attention and become a hot research topic …

N6-methyladenosine methyltransferases: functions, regulation, and clinical potential

W Huang, TQ Chen, K Fang, ZC Zeng, H Ye… - Journal of Hematology & …, 2021 - Springer
Abstract N6-methyladenosine (m6A) has emerged as an abundant modification throughout
the transcriptome with widespread functions in protein-coding and noncoding RNAs. It …

m6A methylated EphA2 and VEGFA through IGF2BP2/3 regulation promotes vasculogenic mimicry in colorectal cancer via PI3K/AKT and ERK1/2 signaling

X Liu, H He, F Zhang, X Hu, F Bi, K Li, H Yu… - Cell death & …, 2022 - nature.com
Exploring the epigenetic regulation mechanism of colorectal cancer (CRC) from the
perspective of N6-methyladenosine (m6A) modification may provide a new target for tumor …

CRISPR/Cas: a Nobel Prize award-winning precise genome editing technology for gene therapy and crop improvement

C Li, E Brant, H Budak, B Zhang - Journal of Zhejiang University-SCIENCE …, 2021 - Springer
Since it was first recognized in bacteria and archaea as a mechanism for innate viral
immunity in the early 2010s, clustered regularly interspaced short palindromic repeats …