The field of isotope effects has expanded exponentially in the last decade, and researchers
are finding isotopes increasingly useful in their studies. Bringing literature on the subject up …

The three-dimensional structure of glycosidases and of their complexes and the study of
transition-state mimics reveal structural details that correlate with mechanism. Of particular …

Experimental analysis of enzymatic transition-state structures uses kinetic isotope effects
(KIEs) to report on bonding and geometry differences between reactants and the transition …

This review focuses on the chemistry performed by base excision repair (BER) enzymes,
enzymes that remove nucleobases from DNA in the first step of the repair of many types of …

This graduate textbook is aimed at providing researchers new to the subject with information
on the structure and mechanisms in the chemistry, biochemistry or processing of …

Transition state theory teaches that chemically stable mimics of enzymatic transition states
will bind tightly to their cognate enzymes. Kinetic isotope effects combined with …

Escherichia coli 5′-methylthioadenosine/S-adenosyl-homocysteine nucleosidase (MTAN)
hydrolyzes its substrates to form adenine and 5-methylthioribose (MTR) or S …

Immucillin-H [ImmH;(1 S)-1-(9-deazahypoxanthin-9-yl)-1, 4-dideoxy-1, 4-imino-d-ribitol] is a
23 pM inhibitor of bovine purine nucleoside phosphorylase (PNP) specifically designed as a …

Recent studies have shown that Plasmodium falciparum is sensitive to a purine salvage
block at purine nucleoside phosphorylase (PNP) and that human PNP is a target for T-cell …

The DNA repair enzyme uracil DNA glycosylase catalyzes the first step in the uracil base
excision repair pathway, the hydrolytic cleavage of the N-glycosidic bond of deoxyuridine in …