Vitamin A, acting through its metabolite, all-trans-retinoic acid, is a potent transcriptional
regulator affecting expression levels of hundreds of genes through retinoic acid response …

Several epidemiologic studies have shown that diets rich in fruits and vegetables reduce the
risk of developing several chronic diseases, such as type 2 diabetes, atherosclerosis, and …

Background: In developed countries, the extension of human life is increasingly
accompanied by a progressive increase in neurodegenerative diseases, most of which do …

Regulation of transcription factor Nrf2 (NF-E2-related factor 2) involves redox-sensitive
proteasomal degradation via the E3 ubiquitin ligase Keap1/Cul3. However, Nrf2 is …

Recognition and repair of cellular damage is crucial if organisms are to survive harmful
environmental conditions. In mammals, the Keap1 protein orchestrates this response, but …

Significance: Our current knowledge of the pathophysiology and molecular mechanisms
causing psychiatric disorders is modest, but genetic susceptibility and environmental factors …

Abstract The Keap1-Nrf2 system plays pivotal roles in defense mechanisms by regulating
cellular redox homeostasis. Nrf2 is an inducible transcription factor that activates a battery of …

Multiple genetic and environmental factors play a role in the development and progression
of Parkinson's disease (PD). The main neuropathological hallmark of PD is the degeneration …

Current therapies for motor symptoms of Parkinson's disease (PD) are based on dopamine
replacement. However, the disease progression remains unaffected, because of continuous …

Mitochondria have been largely described as the powerhouse of the cell and recent findings
demonstrate that this organelle is fundamental for neurogenesis. The mechanisms …