The roles of structural dynamics in the cellular functions of RNAs
RNAs fold into 3D structures that range from simple helical elements to complex tertiary
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …
Long noncoding RNAs and human disease
O Wapinski, HY Chang - Trends in cell biology, 2011 - cell.com
A new class of transcripts, long noncoding RNAs (lncRNAs), has been recently found to be
pervasively transcribed in the genome. Multiple lines of evidence increasingly link mutations …
pervasively transcribed in the genome. Multiple lines of evidence increasingly link mutations …
Thoughts on how to think (and talk) about RNA structure
Recent events have pushed RNA research into the spotlight. Continued discoveries of RNA
with unexpected diverse functions in healthy and diseased cells, such as the role of RNA as …
with unexpected diverse functions in healthy and diseased cells, such as the role of RNA as …
Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance
Despite advances in biology and therapeutic modalities, existence of highly tumorigenic
glioma stem-like cells (GSCs) makes glioblastomas (GBMs) invincible. N6-methyl adenosine …
glioma stem-like cells (GSCs) makes glioblastomas (GBMs) invincible. N6-methyl adenosine …
Determination of RNA structural diversity and its role in HIV-1 RNA splicing
Abstract Human immunodeficiency virus 1 (HIV-1) is a retrovirus with a ten-kilobase single-
stranded RNA genome. HIV-1 must express all of its gene products from a single primary …
stranded RNA genome. HIV-1 must express all of its gene products from a single primary …
Insights into RNA structure and function from genome-wide studies
SA Mortimer, MA Kidwell, JA Doudna - Nature Reviews Genetics, 2014 - nature.com
A comprehensive understanding of RNA structure will provide fundamental insights into the
cellular function of both coding and non-coding RNAs. Although many RNA structures have …
cellular function of both coding and non-coding RNAs. Although many RNA structures have …
Landscape and variation of RNA secondary structure across the human transcriptome
In parallel to the genetic code for protein synthesis, a second layer of information is
embedded in all RNA transcripts in the form of RNA structure. RNA structure influences …
embedded in all RNA transcripts in the form of RNA structure. RNA structure influences …
A novel long noncoding RNA SP100-AS1 induces radioresistance of colorectal cancer via sponging miR-622 and stabilizing ATG3
Y Zhou, Y Shao, W Hu, J Zhang, Y Shi… - Cell Death & …, 2023 - nature.com
Although radiotherapy is an essential modality in the treatment of colorectal cancer (CRC),
the incidence of radioresistance remains high clinically. Long noncoding RNAs (lncRNAs) …
the incidence of radioresistance remains high clinically. Long noncoding RNAs (lncRNAs) …
Understanding the transcriptome through RNA structure
RNA structure is crucial for gene regulation and function. In the past, transcriptomes have
largely been parsed by primary sequences and expression levels, but it is now becoming …
largely been parsed by primary sequences and expression levels, but it is now becoming …
Predicting dynamic cellular protein–RNA interactions by deep learning using in vivo RNA structures
Interactions with RNA-binding proteins (RBPs) are integral to RNA function and cellular
regulation, and dynamically reflect specific cellular conditions. However, presently available …
regulation, and dynamically reflect specific cellular conditions. However, presently available …