Molecular biology of atherosclerosis
PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease
AC Boese, SC Kim, KJ Yin, JP Lee… - American Journal of …, 2017 - journals.physiology.org
Sex differences between women and men are often overlooked and underappreciated when
studying the cardiovascular system. It has been long assumed that men and women are …
studying the cardiovascular system. It has been long assumed that men and women are …
Animal models of cardiovascular diseases
C Zaragoza, C Gomez-Guerrero… - BioMed Research …, 2011 - Wiley Online Library
Cardiovascular diseases are the first leading cause of death and morbidity in developed
countries. The use of animal models have contributed to increase our knowledge, providing …
countries. The use of animal models have contributed to increase our knowledge, providing …
Structure and functions of angiotensinogen
H Lu, LA Cassis, CW Vander Kooi… - Hypertension Research, 2016 - nature.com
Angiotensinogen (AGT) is the sole precursor of all angiotensin peptides. Although AGT is
generally considered as a passive substrate of the renin–angiotensin system, there is …
generally considered as a passive substrate of the renin–angiotensin system, there is …
Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II–induced aortic aneurysms
Inflammation and oxidative stress are pathogenic mediators of many diseases, but
molecules that could be therapeutic targets remain elusive. Inflammation and matrix …
molecules that could be therapeutic targets remain elusive. Inflammation and matrix …
Renin-angiotensin system and cardiovascular functions
CH Wu, S Mohammadmoradi, JZ Chen… - … , and vascular biology, 2018 - Am Heart Assoc
Wu et al The RAS and Cardiovascular Functions e109 homocysteine decreased
antihypertensive effect of enalapril, an ACE inhibitor, in chronic hypertensive patients. 61 …
antihypertensive effect of enalapril, an ACE inhibitor, in chronic hypertensive patients. 61 …
Tissue specific up regulation of ACE2 in rabbit model of atherosclerosis by atorvastatin: role of epigenetic histone modifications
Growing body of evidence points out the crucial role of ACE2 in preventing atherosclerosis.
However, data on how atherosclerosis affects ACE2 expression in heart and kidney remains …
However, data on how atherosclerosis affects ACE2 expression in heart and kidney remains …
Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation
SB Police, SE Thatcher, R Charnigo… - … , and vascular biology, 2009 - Am Heart Assoc
Objective—Obesity promotes macrophage infiltration into adipose tissue and is associated
with increases in several cardiovascular diseases. Infusion of angiotensin II (AngII) to mice …
with increases in several cardiovascular diseases. Infusion of angiotensin II (AngII) to mice …
Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice
M Gupte, SE Thatcher, CM Boustany-Kari… - … , and vascular biology, 2012 - Am Heart Assoc
Objectives—Obesity promotes hypertension, but it is unclear if sex differences exist in
obesity-related hypertension. Angiotensin converting enzyme 2 (ACE2) converts …
obesity-related hypertension. Angiotensin converting enzyme 2 (ACE2) converts …
Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II–induced aortic aneurysm
Objective—Abdominal aortic aneurysm (AAA) is considered a chronic inflammatory disease;
however, the molecular basis underlying the sterile inflammatory response involved in the …
however, the molecular basis underlying the sterile inflammatory response involved in the …