Molecular biology of atherosclerosis

PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease

AC Boese, SC Kim, KJ Yin, JP Lee… - American Journal of …, 2017 - journals.physiology.org
Sex differences between women and men are often overlooked and underappreciated when
studying the cardiovascular system. It has been long assumed that men and women are …

Animal models of cardiovascular diseases

C Zaragoza, C Gomez-Guerrero… - BioMed Research …, 2011 - Wiley Online Library
Cardiovascular diseases are the first leading cause of death and morbidity in developed
countries. The use of animal models have contributed to increase our knowledge, providing …

Structure and functions of angiotensinogen

H Lu, LA Cassis, CW Vander Kooi… - Hypertension Research, 2016 - nature.com
Angiotensinogen (AGT) is the sole precursor of all angiotensin peptides. Although AGT is
generally considered as a passive substrate of the renin–angiotensin system, there is …

Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II–induced aortic aneurysms

K Satoh, P Nigro, T Matoba, MR O'dell, Z Cui, X Shi… - Nature medicine, 2009 - nature.com
Inflammation and oxidative stress are pathogenic mediators of many diseases, but
molecules that could be therapeutic targets remain elusive. Inflammation and matrix …

Renin-angiotensin system and cardiovascular functions

CH Wu, S Mohammadmoradi, JZ Chen… - … , and vascular biology, 2018 - Am Heart Assoc
Wu et al The RAS and Cardiovascular Functions e109 homocysteine decreased
antihypertensive effect of enalapril, an ACE inhibitor, in chronic hypertensive patients. 61 …

Tissue specific up regulation of ACE2 in rabbit model of atherosclerosis by atorvastatin: role of epigenetic histone modifications

K Tikoo, G Patel, S Kumar, PA Karpe… - Biochemical …, 2015 - Elsevier
Growing body of evidence points out the crucial role of ACE2 in preventing atherosclerosis.
However, data on how atherosclerosis affects ACE2 expression in heart and kidney remains …

Obesity promotes inflammation in periaortic adipose tissue and angiotensin II-induced abdominal aortic aneurysm formation

SB Police, SE Thatcher, R Charnigo… - … , and vascular biology, 2009 - Am Heart Assoc
Objective—Obesity promotes macrophage infiltration into adipose tissue and is associated
with increases in several cardiovascular diseases. Infusion of angiotensin II (AngII) to mice …

Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice

M Gupte, SE Thatcher, CM Boustany-Kari… - … , and vascular biology, 2012 - Am Heart Assoc
Objectives—Obesity promotes hypertension, but it is unclear if sex differences exist in
obesity-related hypertension. Angiotensin converting enzyme 2 (ACE2) converts …

Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II–induced aortic aneurysm

F Usui, K Shirasuna, H Kimura, K Tatsumi… - … , and vascular biology, 2015 - Am Heart Assoc
Objective—Abdominal aortic aneurysm (AAA) is considered a chronic inflammatory disease;
however, the molecular basis underlying the sterile inflammatory response involved in the …