This review focuses on primary cultures of human prostatic epithelial cells and their
applications as models of normal and malignant biological behavior. Current abilities to …

The aberrant behavior of cancer reflects upregulation of certain oncogenic signaling
pathways that promote proliferation, inhibit apoptosis, and enable the cancer to spread and …

The epidermal growth factor receptor (EGFR) is one of most potent oncogenes that are
commonly altered in cancers. As a receptor tyrosine kinase, EGFR's kinase activity has been …

Prostate cancer is the most common cancer in men. Advanced prostate cancer spreading
beyond the gland is incurable. Identifying factors that regulate the spread of tumor into the …

The ability of a tumor cell population to grow exponentially represents an imbalance
between cellular proliferation and cellular attrition. There is an overwhelming body of …

The type 1 insulin-like growth factor receptor (IGF-1R) plays an essential role in mammalian
growth and development, and has emerged as a candidate therapeutic target in the …

Prostate cancer (PCa) is the second most common malignancy among men worldwide.
Although early-stage disease is curable, advanced stage PCa is mostly incurable and …

Although the blockade of the hedgehog cascade by using cyclopamine has been reported to
inhibit the growth of some cancer cell types, few studies on the mechanism by which this …

Purpose: Receptor tyrosine kinases of the ErbB family play important roles in the control of
tumor growth. Vascular endothelial growth factor (VEGF) stimulates endothelial cell …

The deregulation of the epidermal growth factor receptor (EGFR) pathway plays a major role
in the pathogenesis of prostate cancer (PCa). However, therapies targeting EGFR have …