Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

Purpose: The aim of this survey is to critically review the available information on one-
electron oxidation reactions of nucleobases in cellular DNA with emphasis on damage …

The exposure of guanine in the oligonucleotide 5′-d (TCGCT) to one-electron oxidants
leads initially to the formation of the guanine radical cation G•+, its deptotonation product G …

Radically different: Contrary to previous proposals, the main reaction of the HO. radical with
guanosine or 2′‐deoxyguanosine is the hydrogen abstraction from the NH2 moiety to give …

An important feature of the common DNA oxidation product 8-oxo-7, 8-dihydroguanine (OG)
is its susceptibility to further oxidation that produces guanidinohydantoin (Gh) and …

Despite extensive investigation of the irreversible oxidations undergone by proteins in vitro
and in vivo, the products formed from the oxidation of Trp residues remain incompletely …

Nitrosoperoxycarbonate derived from the combination of carbon dioxide and peroxynitrite is
an important chemical mediator of inflammation. In aqueous solutions, it rapidly …

DNA sequence context has emerged as a critical determinant of the location and quantity of
nucleobase damage caused by many oxidizing agents. However, the complexity of …

The spiroiminodihydantoins (Sp) are highly mutagenic oxidation products of guanine and 8-
oxo-7, 8-dihydroguanine in DNA. The Sp lesions have recently been detected in the liver …

The oxidation of guanine by triplet benzophenone in the presence of lysine has been shown
to produce mono-and dilysine-substituted spiroiminodihydantion products, 8-Lys-Sp and 5 …