Infections arising from multidrug-resistant pathogenic bacteria are spreading rapidly
throughout the world and threaten to become untreatable. The origins of resistance are …

Tripartite efflux pumps and the related type 1 secretion systems (T1SSs) in Gram-negative
organisms are diverse in function, energization, and structural organization. They form …

Bacterial multidrug efflux pumps have come to prominence in human and veterinary
pathogenesis because they help bacteria protect themselves against the antimicrobials …

Gram‐negative bacteria are intrinsically resistant against cytotoxic substances by means of
their outer membrane and a network of multidrug efflux systems, acting in synergy. Efflux …

The increasing emergence of antimicrobial resistance in staphylococcal bacteria is a major
health threat worldwide due to significant morbidity and mortality resulting from their …

Efflux transporters of the RND family confer resistance to multiple antibiotics in Gram-
negative bacteria. Here, we identify and chemically optimize pyridylpiperazine-based …

Acinetobacter spp. have become of increased clinical importance as studies have shown the
antimicrobial resistant potential of these species. Efflux pumps can lead to reduced …

The rise in multidrug resistance (MDR) is one of the greatest threats to human health
worldwide. MDR in bacterial pathogens is a major challenge in healthcare, as bacterial …

Multidrug resistant (MDR) bacteria are a global threat with many common infections
becoming increasingly difficult to eliminate. While significant effort has gone into the …

Efflux pumps are a serious challenge for the development of antibacterial agents.
Overcoming efflux requires an in-depth understanding of efflux pump functions, specificities …