[HTML][HTML] Increased risk of aging-related neurodegenerative disease after traumatic brain injury

S Barker, BD Paul, AA Pieper - Biomedicines, 2023 - mdpi.com
Traumatic brain injury (TBI) survivors frequently suffer from chronically progressive
complications, including significantly increased risk of developing aging-related …

Translational selenium nanoparticles to attenuate allergic dermatitis through Nrf2-Keap1-driven activation of selenoproteins

B Xie, D Zeng, M Yang, Z Tang, L He, T Chen - ACS nano, 2023 - ACS Publications
Easy recurrence and strong treatment side effects significantly limit the clinical treatment of
allergic dermatitis. The human trace element selenium (Se) plays essential roles in redox …

The pathophysiology of trigeminal neuralgia: a molecular review

B Dong, R Xu, M Lim - Journal of neurosurgery, 2023 - thejns.org
OBJECTIVE The goal of this study was to provide a comprehensive overview of the current
understanding of molecular and genetic mechanisms underlying the pathophysiology of …

Discovery of 1H-Imidazo[4,5-b]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain

X Chen, D Cao, C Liu, F Meng, Z Zhang… - Journal of medicinal …, 2023 - ACS Publications
Neuropathic pain (NP) is an intolerable pain syndrome that arises from continuous
inflammation and excitability after nerve injury. Only a few NP therapeutics are currently …

Microglial Nrf2/HO-1 signaling gates remifentanil-induced hyperalgesia via suppressing TRPV4-mediated M1 polarization

X Liu, H Cai, L Peng, H Ma, Y Yan, W Li… - Free Radical Biology and …, 2024 - Elsevier
Remifentanil-induced hyperalgesia (RIH) represents a significant clinical challenge due to
the widespread use of opioids in pain management. However, the molecular and cellular …

RTA-408 Regulates p-NF-κB/TSLP/STAT5 Signaling to Ameliorate Nociceptive Hypersensitivity in Chronic Constriction Injury Rats

YY Lu, HP Tsai, TH Tsai, HC Miao, ZH Zhang… - Molecular …, 2024 - Springer
Neuropathic pain following nerve injury is a complex condition, which often puts a negative
impact on life and remains a sustained problem. To make pain management better is of …

TRPA1: A promising target for pulmonary fibrosis?

C Li, J Xu, A Abdurehim, Q Sun, J Xie… - European Journal of …, 2023 - Elsevier
Pulmonary fibrosis is a disease characterized by progressive scar formation and the ultimate
manifestation of numerous lung diseases. It is known as “cancer that is not cancer” and has …

Communicating pain: emerging axonal signaling in peripheral neuropathic pain

L Testa, S Dotta, A Vercelli, L Marvaldi - Frontiers in Neuroanatomy, 2024 - frontiersin.org
Peripheral nerve damage often leads to the onset of neuropathic pain (NeuP). This condition
afflicts millions of people, significantly burdening healthcare systems and putting strain on …

Trigeminal neuralgia as a primary demyelinating disease: potential multimodal evidence and remaining controversies

SH Mousavi, JW Lindsey, KN Westlund, SRA Alles - The Journal of Pain, 2024 - Elsevier
Trigeminal neuralgia is a heterogeneous disorder with likely multifactorial and complex
etiology; however, trigeminal nerve demyelination and injury are observed in almost all …

Preoperative characteristics and postoperative pain outcomes in trigeminal neuralgia with concomitant autoimmune disease

AL Kalluri, RJ So, KR Ran, ME Xie, C Kilgore… - …, 2022 - journals.lww.com
METHODS: A retrospective review of all patients who underwent an MVD at our institution
between 2007 and 2020 was conducted. The presence and type of autoimmune disease …