Multiscale modeling of blood flow: from single cells to blood rheology

DA Fedosov, H Noguchi, G Gompper - Biomechanics and modeling in …, 2014 - Springer
Mesoscale simulations of blood flow, where the red blood cells are described as deformable
closed shells with a membrane characterized by bending rigidity and stretching elasticity …

Hydrodynamics in cell studies

D Huber, A Oskooei, X Casadevall i Solvas… - Chemical …, 2018 - ACS Publications
Hydrodynamic phenomena are ubiquitous in living organisms and can be used to
manipulate cells or emulate physiological microenvironments experienced in vivo …

Red blood cell shape transitions and dynamics in time-dependent capillary flows

SM Recktenwald, K Graessel, FM Maurer, T John… - Biophysical …, 2022 - cell.com
The dynamics of single red blood cells (RBCs) determine microvascular blood flow by
adapting their shape to the flow conditions in the narrow vessels. In this study, we explore …

Numerical–experimental observation of shape bistability of red blood cells flowing in a microchannel

A Guckenberger, A Kihm, T John, C Wagner, S Gekle - Soft Matter, 2018 - pubs.rsc.org
Red blood cells flowing through capillaries assume a wide variety of different shapes owing
to their high deformability. Predicting the realized shapes is a complex field as they are …

Fluid vesicles in flow

D Abreu, M Levant, V Steinberg, U Seifert - Advances in colloid and …, 2014 - Elsevier
We review the dynamical behavior of giant fluid vesicles in various types of external
hydrodynamic flow. The interplay between stresses arising from membrane elasticity …

Modeling thrombosis in silico: Frontiers, challenges, unresolved problems and milestones

AV Belyaev, JL Dunster, JM Gibbins, MA Panteleev… - Physics of life …, 2018 - Elsevier
Hemostasis is a complex physiological mechanism that functions to maintain vascular
integrity under any conditions. Its primary components are blood platelets and a coagulation …

Deformation of spherical compound capsules in simple shear flow

ZY Luo, L He, BF Bai - Journal of Fluid Mechanics, 2015 - cambridge.org
The deformation of a compound capsule (an elastic capsule with a smaller capsule inside)
in simple shear flow is studied by using three-dimensional numerical simulations based on a …

Microfluidics approach to the mechanical properties of red blood cell membrane and their effect on blood rheology

C Trejo-Soto, GR Lázaro, I Pagonabarraga… - Membranes, 2022 - mdpi.com
In this article, we describe the general features of red blood cell membranes and their effect
on blood flow and blood rheology. We first present a basic description of membranes and …

Effect of cell age and membrane rigidity on red blood cell shape in capillary flow

M Nouaman, A Darras, T John, G Simionato, MAE Rab… - Cells, 2023 - mdpi.com
Blood flow in the microcirculatory system is crucially affected by intrinsic red blood cell
(RBC) properties, such as their deformability. In the smallest vessels of this network, RBCs …

Numerical simulations of complex fluid-fluid interface dynamics

T Krüger, S Frijters, F Günther, B Kaoui… - The European Physical …, 2013 - Springer
Interfaces between two fluids are ubiquitous and of special importance for industrial
applications, eg, stabilisation of emulsions. The dynamics of fluid-fluid interfaces is difficult to …