Ageing is defined as a progressive decline of homeostasis that occurs after the reproductive
phase of life is complete, which is thought to arise because of impaired DNA repair following …

In healthy individuals, billions of cells die by apoptosis each day. Clearance of these
apoptotic cells, termed “efferocytosis,” must be efficient to prevent secondary necrosis and …

We used heparosan (HEP) polysaccharides for controlling nanoparticle delivery to innate
immune cells. Our results show that HEP-coated nanoparticles were endocytosed in a time …

The efficient clearance of apoptotic cells is an evolutionarily conserved process crucial for
homeostasis in multicellular organisms. The clearance involves a series of steps that …

Background and Aims Phagocytosis (efferocytosis) of apoptotic neutrophils by macrophages
anchors the resolution of intestinal inflammation. Efferocytosis prevents secondary necrosis …

Integrins, the extracellular matrix receptors that facilitate cell adhesion and migration, are
necessary for organ morphogenesis; however, their role in maintaining adult tissue …

Lung diseases such as emphysema, interstitial fibrosis, and pulmonary vascular diseases
cause significant morbidity and mortality, but despite substantial mechanistic understanding …

Chronic cigarette smoke (CS) exposure provokes variable changes in the lungs, and
emphysema is an important feature of chronic obstructive pulmonary disease. The …

Emphysema is the major component of chronic obstructive pulmonary disease (COPD).
During emphysema, elastin breakdown in the lung tissue originates from the release of large …

Efferocytosis is imperative to maintain lung homeostasis and control inflammation.
Populations of lung macrophages are the main efferocytes in this tissue, responsible for …