Given that cardiovascular safety concerns remain the leading cause of drug attrition at the
preclinical drug development stage, the National Center for Toxicological Research of the …

Introduction Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes is one of
the most widely used cell-based models that resulted from the discovery of how non …

Background: The concept of chemical agents having properties that confer potential hazard
called key characteristics (KCs) was first developed to identify carcinogenic hazards …

Background: Risk assessment of chemical mixtures or complex substances remains a major
methodological challenge due to lack of available hazard or exposure data. Therefore, risk …

The potential for cardiotoxicity is carefully evaluated for pharmaceuticals, as it is a major
safety liability. However, environmental chemicals are seldom tested for their cardiotoxic …

Heart disease remains a significant human health burden worldwide with a significant
fraction of morbidity attributable to environmental exposures. However, the extent to which …

Addressing inter-and intra-species differences in potential hazardous effects of chemicals
remains a long-standing challenge in human health risk assessment that is typically …

Background: Xenobiotic metabolism is complex, and accounting for bioactivation and
detoxification processes of chemicals remains among the most challenging aspects for …

The lack of adequate toxicity data for the vast majority of chemicals in the environment has
spurred the development of new approach methodologies (NAMs). This study aimed to …

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes are an established
model for testing potential chemical hazards. Interindividual variability in toxicodynamic …