[HTML][HTML] Molecular Mechanisms of HIV Protease Inhibitors Against HPV-Associated Cervical Cancer: Restoration of TP53 Tumour Suppressor Activities

L Makgoo, S Mosebi, Z Mbita - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Cervical cancer is a Human Papilloma virus-related disease, which is on the rise in a
number of countries, globally. Two essential oncogenes, E6 and E7, drive cell …

[HTML][HTML] The role of MMP-9 and MMP-9 inhibition in different types of thyroid carcinoma

Z Li, J Wei, B Chen, Y Wang, S Yang, K Wu, X Meng - Molecules, 2023 - mdpi.com
Matrix metalloproteinase-9 (MMP-9), one of the most investigated and studied biomarkers of
the MMPs family, is a zinc-dependent proteolytic metalloenzyme whose primary function is …

[HTML][HTML] Effect of Kegel pelvic floor muscle exercise combined with clean intermittent self-catheterization on urinary retention after radical hysterectomy for cervical …

J Zong, M You, C Li - Pakistan Journal of Medical Sciences, 2022 - ncbi.nlm.nih.gov
Objectives: To investigate the effect of Kegel pelvic floor muscle training combined with
clean intermittent self-catheterization on patients with cervical cancer, and to analyze the risk …

[HTML][HTML] Clinical efficacy of the HIV protease inhibitor indinavir in combination with chemotherapy for advanced classic kaposi sarcoma treatment: a single-arm, phase …

C Sgadari, B Scoppio, O Picconi… - Cancer Research …, 2024 - aacrjournals.org
Kaposi sarcoma is a rare angioproliferative disease associated with human herpes virus-8
(HHV-8) infection. Kaposi sarcoma is frequent and aggressive in HIV-infected people …

[HTML][HTML] Topical Protease Inhibitor Decreases Anal Carcinogenesis in a Transgenic Mouse Model of HPV Anal Disease

LC Gunder, HR Johnson, E Yao, TH Moyer, HA Green… - Viruses, 2023 - mdpi.com
Anal cancer is a major health problem. This study seeks to determine if the topical protease
inhibitor Saquinavir (SQV), is effective at the prevention of anal cancer in transgenic mice …

Synergistic combination of ritonavir and cisplatin as an efficacious therapy in human cervical cancer cells: a computational drug discovery and in vitro insight

D Swami, P Mudaliar, YS Bichu… - Journal of …, 2023 - Taylor & Francis
HIV-protease inhibitor Ritonavir (RTV) is a clinical-stage drug. We exhibit here the
synergistic effect of RTV coupled with cisplatin as potential combination therapy for …

Increased risk of subsequent primary lung cancer among female hormone-related cancer patients: A meta-analysis based on over four million cases

Y Wang, W Song, H Wang, G Zhu, Y Li… - Chinese Medical …, 2024 - mednexus.org
Background: The incidence rate of lung cancer in women has significantly increased over
the past decade, and previous evidence has indicated a significant relationship between the …

[HTML][HTML] Indinavir

EB Pollak, M Parmar - StatPearls [Internet], 2022 - nova.elsevierpure.com
Indinavir is an alpha-amino acid amide protease inhibitor used as a treatment therapy for
Human immunodeficiency virus (HIV) infections, which can lead to acquired …

[PDF][PDF] Comprehensive review on The tools: The approach to overcome mutations in RNA Splicing

M Aslam - Animal Science Journal, 2021 - researchgate.net
Cancer is the main cause when the mutation in the genes occur which may be the lead to
several type of mutations in our body. Usually cancer that is common by the mutation of …

[HTML][HTML] Mechanism of Action

EB Pollak, M Parmar - europepmc.org
Indinavir acts through a competitive inhibition mechanism. The medication binds the active
catalytic site of HIV protease, inhibiting the enzyme's ability to cleave polypeptides into …