Abstract Drew Pardoll (Johns Hopkins Oncology Center) examines prospects for therapeutic
cancer vaccines. Considering how it is that the immune system fails to recognize and …

Immunological self-tolerance is ensured by eliminating or inhibiting self-reactive lymphocyte
clones, creating physical or functional holes in the B-and T-lymphocyte antigen receptor …

Many body surfaces harbor organ-specific γδ T cell compartments that contribute to tissue
integrity. Thus, murine dendritic epidermal T cells (DETCs) uniquely expressing T cell …

It has been shown that mesenchymal stem cells (MSCs) induce T cells to become
unresponsive. We characterized the phenotype of these T cells by dissecting the effect of …

Activation of naive CD8 T cells to undergo clonal expansion and develop effector function
requires three signals:(a) Ag,(b) costimulation, and (c) IL-12 or adjuvant. The requirement for …

To address the mechanisms of tolerance to extrathymic proteins, we have generated
transgenic mice expressing the lymphocytic choriomeningitis viral (LCMV) glycoprotein (GP) …

The ability to discriminate between self and nonself antigens is vital to the functioning of the
immune system as a specific defense against invading microorganisms. Failure of the …

T lymphocytes undergo selection events not only in the thymus, but also after they leave the
thymus and reside in the periphery. Peripheral selection was found to be dependent on T …

Naturally acquired immunological self-tolerance is not entirely accounted for by clonal
deletion, anergy, and ignorance. It is now well established that the T cell-repertoire of …

By generating two types of transgenic mice we have investigated how extrathymic events
can contribute to self tolerance. The major histocompatibility complex class I gene Kb was …