In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the
limited regenerative capacity of the myocardium, resulting in the formation of a collagen …

The immune system plays a central role in tissue repair and regeneration. Indeed, the
immune response to tissue injury is crucial in determining the speed and the outcome of the …

Abstract Aims Mesenchymal stromal cells (MSCs) gradually become attractive candidates
for cardiac inflammation modulation, yet understanding of the mechanism remains elusive …

Heart failure is a consequence of various cardiovascular diseases and associated with poor
prognosis. Despite progress in the treatment of heart failure in the past decades, prevalence …

Inflammatory processes are firmly established as central to the development and
complications of cardiovascular diseases. Elevated levels of inflammatory markers have …

Myocardial infarction triggers an intense inflammatory response that is essential for cardiac
repair, but which is also implicated in the pathogenesis of postinfarction remodelling and …

Toll‐like receptor 4 (TLR4) belongs to the family of pattern recognition receptors (PRRs).
They are highly conserved receptors that recognize conserved pathogen‐associated …

Despite the advances that have been made in developing new therapeutics, cardiovascular
disease remains the leading cause of worldwide mortality. Therefore, understanding the …

The CADUCEUS trial of cardiosphere-derived cells (CDCs) has shown that it may be
possible to regenerate injured heart muscle previously thought to be permanently scarred …

Regulated necrosis, termed necroptosis, is negatively regulated by caspase-8 and is
dependent on the kinase activity of RIPK1 and RIPK3. Necroptosis leads to rapid plasma …