Ovarian cancer remains one of the most challenging malignancies to treat. Targeted
therapies such as poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as one of …

Airway remodeling is generally quite broadly defined as any change in composition,
distribution, thickness, mass or volume and/or number of structural components observed in …

As aerobic organisms, we are continuously and throughout our lifetime subjected to an
oxidizing atmosphere and, most often, to environmental threats. The lung is the internal …

Abstract Objective/Background We aimed to evaluate the risk of PARP inhibitors (PARPis)
causing pneumonitis in randomized controlled trials (RCTs) and in the real-world practice …

Idiopathic pulmonary fibrosis is a severe disease characterized by excessive myofibroblast
proliferation, extracellular matrix and fibrils deposition, remodelling of lung parenchyma and …

2-((Dimethylamino) methyl)-9-hydroxythieno [2, 3-c] isoquinolin-5 (4 H)-one (HYDAMTIQ), a
potent PARP1/2 inhibitor, is currently being evaluated in preclinical trials for the treatment of …

Asthma, acute lung injury (ALI), and chronic obstructive pulmonary disease (COPD) are lung
inflammatory disorders with a common outcome, that is, difficulty in breathing …

PARP1, the major isoform of a family of ADP-ribosylating enzymes, has been implicated in
the regulation of various biological processes including DNA repair, gene transcription, and …

Superfluous human airway smooth muscle (HASM) cell proliferation is an important
pathological feature of airway remodelling in asthma. This study aimed to determine whether …

Background An important portion of asthmatics do not respond to current therapies. Thus,
the need for new therapeutic drugs is urgent. We have demonstrated a critical role for PARP …