This chapter provides an overview of the early developmental origins of six ocular tissues:
the cornea, lens, ciliary body, iris, neural retina, and retina pigment epithelium. Many of …

The enteric nervous system (ENS) is the largest part of the peripheral nervous system and is
entirely neural crest–derived. It provides the intrinsic innervation of the gut, controlling …

We previously used single-cell transcriptomic analysis to characterize human fetal retinal
development and assessed the degree to which retinal organoids recapitulate normal …

In vivo cell lineage-tracing studies in the vertebrate retina have revealed that the sizes and
cellular compositions of retinal clones are highly variable. It has been challenging to …

In mammals, cerebellar neurons are categorized as glutamatergic or GABAergic, and are
derived from progenitors that express the proneural genes atoh1 or ptf1a, respectively. In …

The nerve cell is a eumetazoan (cnidarians and bilaterians) synapomorphy [1]; this cell type
is absent in sponges, a more ancient phyletic lineage. Here, we demonstrate that despite …

In mammals, retinal direction selectivity originates from GABAergic/cholinergic amacrine
cells (ACs) specifically expressing the sox2 gene. However, the cellular diversity of …

The mammalian retina contains multiple neurons, each of which contributes differentially to
visual processing. Of these retinal neurons, amacrine cells have recently come to prime light …

The vertebrate retina is regarded as a simple part of the central nervous system (CNS) and
thus amenable to investigations of the determinants of cell fate. Its five neuronal cell classes …

Background The vertebrate retina is composed of five major types of neurons: three
excitatory (photoreceptors, bipolar cells and ganglion cells) and two inhibitory (horizontal …